Huang Caijuan, Xu Ying, Guan Yibing, Liu Jingjing, Yang Haiping
Department of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Department of Urology, The First Affiliated Hospital of Zhengzhou university, Zhengzhou, China.
Sci Rep. 2025 Aug 6;15(1):28797. doi: 10.1038/s41598-025-11401-3.
The relationship between lipid accumulation products (LAP) and overactive bladder (OAB) has not been explored. This study aims to investigate the relationship between LAP and OAB and the mediating role of depression. Data from seven cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 were used to analyze the relationship between LAP and OAB. The association between LAP and OAB was estimated using multivariable logistic regression models, and the dose-response relationship was estimated using restricted cubic splines (RCS). In addition, subgroup analysis was also performed. Moreover, important factors associated with OAB were identified by Random Forest (RF). Finally, the extent to which depression mediates the association between LAP and OAB was investigated. A total of 13,861 participants with an average age of 49.65 years were enrolled, including 6,869 females (50%), of which 2,739 were diagnosed with OAB. The age-adjusted prevalence of OAB gradually increased among the quartile groups of LAP. In the fully adjusted model, there was a significant positive association between Ln and OAB [adjusted odds ratio (AOR): 1.158, 95% CI: 1.073-1.251, P < 0.001]. In the categorical model of LAP, compared with the lowest quartile group of LAP, the prevalence of OAB in the highest quartile group significantly increased after adjustment (AOR: 1.320, 95% CI: 1.105-1.578, P = 0.002). The trend test (P for trend < 0.001) and RCS (P for nonlinearity = 0.196) consistently indicated a linear relationship between LAP and OAB. Subgroup analysis suggested that female gender was an important interaction variable. RF indicated that LAP was the most important factor associated with OAB other than age. Furthermore, in the mediation analysis, depression explained approximately 10% of the association between LAP and OAB. Our research results indicate that there is a linear positive association between LAP and OAB, and there is a significant interaction between gender and LAP. In addition, depression is an important intermediate factor in the association between LAP and OAB.
脂质蓄积产物（LAP）与膀胱过度活动症（OAB）之间的关系尚未得到研究。本研究旨在探讨LAP与OAB之间的关系以及抑郁的中介作用。使用2005年至2018年全国健康与营养检查调查（NHANES）七个周期的数据来分析LAP与OAB之间的关系。使用多变量逻辑回归模型估计LAP与OAB之间的关联，并使用受限立方样条（RCS）估计剂量反应关系。此外，还进行了亚组分析。此外，通过随机森林（RF）确定与OAB相关的重要因素。最后，研究了抑郁介导LAP与OAB之间关联的程度。共纳入13861名平均年龄为49.65岁的参与者，其中6869名女性（50%），其中2739名被诊断为OAB。在LAP四分位数组中，OAB的年龄调整患病率逐渐增加。在完全调整模型中，Ln与OAB之间存在显著正相关[调整优势比（AOR）：1.158，95%可信区间：1.073 - 1.251，P < 0.001]。在LAP的分类模型中，与LAP最低四分位数组相比，最高四分位数组中OAB的患病率在调整后显著增加（AOR：1.320，95%可信区间：1.105 - 1.578，P = 0.002）。趋势检验（趋势P < 0.001）和RCS（非线性P = 0.196）一致表明LAP与OAB之间存在线性关系。亚组分析表明女性性别是一个重要的交互变量。RF表明LAP是除年龄外与OAB相关的最重要因素。此外，在中介分析中，抑郁解释了LAP与OAB之间约10%的关联。我们的研究结果表明，LAP与OAB之间存在线性正相关，性别与LAP之间存在显著交互作用。此外，抑郁是LAP与OAB之间关联的一个重要中间因素。
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