Erickson Deborah R, Kunselman Allen R, Bentley Christina M, Peters Kenneth M, Rovner Eric S, Demers Laurence M, Tomaszewski John E
Department of Surgery (Division of Urology), Pennsylvania State University College of Medicine, Hershey, PA, USA.
J Urol. 2004 Dec;172(6 Pt 1):2256-60. doi: 10.1097/01.ju.0000140956.25590.98.
We determined whether urine methylhistamine (MH) is associated with other clinical features and bladder biopsy findings in interstitial cystitis (IC).
Urine MH and University of Wisconsin symptom scores were measured before and 1 month after bladder distention for IC. Bladder biopsies were done at the time of distention. In new patients with IC who met cystoscopic criteria urine MH was compared before and after distention, and changes in urine MH were compared with changes in symptom scores. Pre-distention urine MH was tested for associations with the results of a symptom questionnaire, symptom response after distention, cystoscopic findings and bladder biopsy findings.
There were no significant associations between urine MH and symptom scores, response to bladder distention, cystoscopic findings or bladder biopsy features, including mast cell count by tryptase staining. Urine MH was similar in new patients with IC who did vs did not meet cystoscopic criteria. Urine MH was similar in new vs chronically treated patients with IC.
Urine MH is unlikely to be useful as an objective marker of the response to bladder distention, as a method to predict which patients will respond to bladder distention or as a noninvasive substitute for bladder biopsy and mast cell counts by tryptase staining.
我们确定了尿甲基组胺（MH）是否与间质性膀胱炎（IC）的其他临床特征及膀胱活检结果相关。
在对IC患者进行膀胱扩张前及扩张后1个月测量尿MH及威斯康星大学症状评分。在扩张时进行膀胱活检。对于符合膀胱镜检查标准的新诊断IC患者，比较扩张前后的尿MH，并将尿MH的变化与症状评分的变化进行比较。对扩张前的尿MH进行检测，以确定其与症状问卷结果、扩张后的症状反应、膀胱镜检查结果及膀胱活检结果之间的关联。
尿MH与症状评分、对膀胱扩张的反应、膀胱镜检查结果或膀胱活检特征（包括通过胰蛋白酶染色计数肥大细胞）之间均无显著关联。符合膀胱镜检查标准与不符合膀胱镜检查标准的新诊断IC患者的尿MH相似。新诊断与长期治疗的IC患者的尿MH相似。
尿MH不太可能作为对膀胱扩张反应的客观标志物、预测哪些患者会对膀胱扩张产生反应的方法，或作为膀胱活检及通过胰蛋白酶染色计数肥大细胞的非侵入性替代方法。
