Neufeld Michael D, Frigon Chantal, Graham Alan S, Mueller Beth A
Department of Pediatrics (M.D.N.), Division of Neonatology, University of Washington, Seattle, WA 98195-6320, USA.
J Perinatol. 2005 Feb;25(2):108-13. doi: 10.1038/sj.jp.7211219.
We tested the hypothesis that term and preterm infants exposed to maternal infection at the time of delivery are at increased risk of developing cerebral palsy (CP).
A population-based case-control study was conducted using Washington State birth certificate data linked to hospital discharge data. Cases (688) were children <or=6 years old, singleton births, hospitalized during 1987 to 1999 with an ICD-9 diagnosis code for CP. Controls were 3,068 singleton birth infants randomly selected from birth records for the same years without CP-related hospitalizations. Infection information was available only for the birth hospitalization.
Infants of women who had any infection during their hospitalization for delivery were at increased risk of CP (odds ratio (OR) 3.1, 95% confidence interval (CI) 2.3 to 4.2). This was observed for term deliveries (OR 1.8, 95% CI 1.1 to 2.8) and preterm deliveries (OR 2.3, 95% CI 1.3 to 4.2).
Our results suggest that maternal infection is a risk factor for CP in both term and preterm infants.
我们检验了以下假设，即足月和早产婴儿在分娩时暴露于母体感染会增加患脑瘫（CP）的风险。
采用华盛顿州出生证明数据与医院出院数据相链接的基于人群的病例对照研究。病例（688例）为年龄≤6岁的单胎出生儿童，于1987年至1999年期间因CP的ICD - 9诊断编码而住院。对照为从同年出生记录中随机选取的3068名单胎出生婴儿，无CP相关住院史。感染信息仅来自出生时的住院情况。
分娩住院期间有任何感染的产妇所生婴儿患CP的风险增加（优势比（OR）3.1，95%置信区间（CI）2.3至4.2）。足月分娩（OR 1.8，95% CI 1.1至2.8）和早产分娩（OR 2.3，95% CI 1.3至4.2）中均观察到这一情况。
我们的结果表明，母体感染是足月和早产婴儿患CP的一个风险因素。
