Meyers J F, Grana W A, Lesker P A
Am J Sports Med. 1979 Mar-Apr;7(2):85-90. doi: 10.1177/036354657900700203.
The anterior cruciate ligaments in 17 knees of 12 mongrel dogs were replaced with one of three porous minimally reactive prosthetic (synthetic) materials. The results show that while the porous materials support the ingrowth of fibrous tissue from the bone of the dog's knee, fatigue failure occurred before sufficient fibrous tissue was incorporated to reconstitute a functional ligament. Further laboratory investigation is necessary before prosthetic materials, currently available, can be used in the unstable human knee.
用三种多孔低反应性假体(合成)材料之一替换了12只杂种狗17个膝关节中的前交叉韧带。结果表明,虽然多孔材料支持狗膝关节骨的纤维组织向内生长,但在有足够的纤维组织整合以重建功能性韧带之前就发生了疲劳失效。在将目前可用的假体材料用于不稳定的人类膝关节之前,还需要进一步的实验室研究。