Onozawa Masahiro, Hashino Satoshi, Kanamori Hiroe, Izumiyama Koh, Yonezumi Masakatsu, Chiba Koji, Kondo Takeshi, Fukuhara Takashi, Tanaka Junji, Imamura Masahiro, Asaka Masahiro
Departments of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Int J Hematol. 2004 Oct;80(3):278-80. doi: 10.1532/ijh97.04010.
Aleukemic leukemia cutis is a rare condition characterized by the invasion of leukemic blasts into the skin before their appearance in the peripheral blood. Leukemia cutis usually occurs in patients with myeloid leukemia, especially the myelomonocytic and monocytic types of acute myeloblastic leukemia. We describe the case of a 62-year-old woman with aleukemic leukemia cutis who developed Philadelphia-positive acute leukemia 1 month after skin involvement. Leukemic cells expressed both myeloid and B-cell lineage surface markers, and monoclonal rearrangement of the immunoglobulin heavy chain was detected by Southern blot analysis. This report is the first of a case of aleukemic leukemia cutis preceding Philadelphia-positive biphenotypic leukemia.
无白血病性白血病皮肤浸润是一种罕见病症，其特征为白血病原始细胞在外周血出现之前就侵入皮肤。白血病皮肤浸润通常发生于髓系白血病患者，尤其是急性髓系白血病的髓单核细胞型和单核细胞型。我们报告一例62岁患无白血病性白血病皮肤浸润的女性病例，其在皮肤受累1个月后发生费城染色体阳性的急性白血病。白血病细胞表达髓系和B细胞系表面标志物，通过Southern印迹分析检测到免疫球蛋白重链的单克隆重排。本报告是首例无白血病性白血病皮肤浸润先于费城染色体阳性双表型白血病的病例。
