Lu Dunyue, Mahmood Asim, Qu Changsheng, Goussev Anton, Lu Mei, Chopp Michael
Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA.
J Neurosurg. 2004 Nov;101(5):822-5. doi: 10.3171/jns.2004.101.5.0822.
Atorvastatin, a beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor, has pleiotropic effects such as improving thrombogenic profile, promoting angiogenesis, and reducing inflammatory responses and has shown promise in enhancing neurological functional improvement and promoting neuroplasticity in animal models of traumatic brain injury (TBI), stroke, and intracranial hemorrhage. The authors tested the effect of atorvastatin on intracranial hematoma after TBI.
Male Wistar rats were subjected to controlled cortical impact, and atorvastatin (1 mg/kg) was orally administered 1 day after TBI and daily for 7 days thereafter. Rats were killed at 1, 8, and 15 days post-TBI. The temporal profile of intraparenchymal hematoma was measured on brain tissue sections by using a MicroComputer Imaging Device and light microscopy.
Data in this study showed that intraparenchymal and intraventricular hemorrhages are present 1 day after TBI and are absorbed at 15 days after TBI. Furthermore, atorvastatin reduces the volume of intracranial hematoma 8 days after TBI.
阿托伐他汀是一种β-羟基-β-甲基戊二酰辅酶A还原酶抑制剂，具有多种效应，如改善血栓形成倾向、促进血管生成以及减轻炎症反应，并且在创伤性脑损伤（TBI）、中风和颅内出血的动物模型中，已显示出在增强神经功能改善和促进神经可塑性方面具有前景。作者测试了阿托伐他汀对TBI后颅内血肿的影响。
雄性Wistar大鼠接受控制性皮质撞击，TBI后1天口服阿托伐他汀（1毫克/千克），此后每天给药，持续7天。在TBI后1、8和15天处死大鼠。使用微型计算机成像设备和光学显微镜在脑组织切片上测量脑实质内血肿的时间变化情况。
本研究数据显示，TBI后1天存在脑实质内和脑室内出血，TBI后15天出血被吸收。此外，阿托伐他汀可减少TBI后8天的颅内血肿体积。
