非处方因素对他汀类药物降低低密度脂蛋白胆固醇的影响。

Impact of nonprescriptive factors on low-density lipoprotein cholesterol reduction with statins.

作者信息

Frolkis Joseph P, Pearce Gregory L, Sprecher Dennis L

机构信息

Division of General Internal Medicine and Health Care Research, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.

出版信息

Am J Cardiol. 2004 Nov 15;94(10):1310-2. doi: 10.1016/j.amjcard.2004.07.122.

DOI:10.1016/j.amjcard.2004.07.122

PMID:15541255

Abstract

Nonprescriptive factors, including patient adherence, can affect the fluctuations in low-density lipoprotein (LDL) cholesterol observed in the clinical setting. In 241 statin-treated patients, although drugs and doses remained fixed, 57% of patients initially successful in reaching LDL cholesterol targets showed subsequent increases in LDL cholesterol. Conversely, 60% of patients who initially failed to reach targets had subsequent reductions in LDL cholesterol, with nearly 1/3 eventually attaining their LDL cholesterol goals.

摘要

包括患者依从性在内的非处方因素会影响临床环境中观察到的低密度脂蛋白（LDL）胆固醇波动。在241例接受他汀类药物治疗的患者中，尽管药物和剂量保持不变，但最初成功达到LDL胆固醇目标的患者中有57%随后LDL胆固醇升高。相反，最初未达到目标的患者中有60%随后LDL胆固醇降低，近三分之一最终实现了LDL胆固醇目标。