作为源自富烯和二氯化钛的潜在抗癌药物的甲氧基苯基取代的ansa-钛茂
Methoxy-phenyl substituted ansa-titanocenes as potential anti-cancer drugs derived from fulvenes and titanium dichloride.
作者信息
Tacke Matthias, Cuffe Laurence P, Gallagher William M, Lou Ying, Mendoza Oscar, Müller-Bunz Helge, Rehmann Franz-Josef K, Sweeney Nigel
机构信息
Chemistry Department, Centre for Synthesis and Chemical Biology (CSCB), University College Dublin, Belfield, Dublin 4, Ireland.
出版信息
J Inorg Biochem. 2004 Dec;98(12):1987-94. doi: 10.1016/j.jinorgbio.2004.09.001.
Starting from 6-(4'-methoxyphenyl)fulvene (1a), 6-(2',4',6'-trimethoxyphenyl)fulvene (1b), or 6-(3',5'-dimethoxyphenyl)fulvene (1c), [1,2-di(cyclopentadienyl)-1,2-di(4'-methoxyphenyl)-ethanediyl] titanium dichloride (2a), [1,2-di(cyclopentadienyl)-1,2-bis(2',4',6'-trimethoxyphenyl)-ethanediyl] titanium dichloride (2b), and [1,2-di(cyclopentadienyl)-1,2-bis(3',5'-dimethoxyphenyl)-ethanediyl] titanium dichloride (2c) were synthesised. When titanocenes 2a-c were tested against pig kidney carcinoma cells (LLC-PK) inhibitory concentrations (IC50) of 2.8 x 10(-4), 3.6 x 10(-4) and 2.1 x 10(-4) M, respectively, were observed.
从6-(4'-甲氧基苯基)富烯(1a)、6-(2',4',6'-三甲氧基苯基)富烯(1b)或6-(3',5'-二甲氧基苯基)富烯(1c)出发，合成了二氯[1,2-二(环戊二烯基)-1,2-二(4'-甲氧基苯基)-乙二基]钛(2a)、二氯[1,2-二(环戊二烯基)-1,2-双(2',4',6'-三甲氧基苯基)-乙二基]钛(2b)和二氯[1,2-二(环戊二烯基)-1,2-双(3',5'-二甲氧基苯基)-乙二基]钛(2c)。当对二茂钛2a - c针对猪肾癌细胞(LLC - PK)进行测试时，分别观察到抑制浓度(IC50)为2.8×10(-4)、3.6×10(-4)和2.1×10(-4)M。
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