Kumar D Krishna, Jose D Amilan, Dastidar Parthasarathi, Das Amitava
Analytical Science Discipline, Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364 002, Gujarat, India.
Langmuir. 2004 Nov 23;20(24):10413-8. doi: 10.1021/la049097j.
A series of pyridyl amides derived from isonicotinic acid, nicotinic acid, and benzoic acid have been synthesized. Only N-(4-pyridyl)isonicotinamide 1 is found to be an efficient hydrogelator with a minimum gelator concentration of 0.37 wt %. A wide range of concentrations (0.37-20 wt %) could be used to form hydrogels. The other amides, namely, N-(3-pyridyl)isonicotinamide 2, N-(2-pyridyl)isonicotinamide 3, N-(phenyl)isonicotinamide 4, N-(4-pyridyl)nicotinamide 5, N-(3-pyridyl)nicotinamide 6, and N-(4-pyridyl)benzamide 7, did not show any gelation properties. Fourier transform infrared spectroscopy, variable temperature 1H NMR, single-crystal diffraction and X-ray powder diffraction (XRPD), and scanning electron microscopy have been used to characterize the gel. Single-crystal diffraction and XRPD studies indicate that the morph responsible for gel formation is different from that in its bulk solid and xerogel.
已经合成了一系列衍生自异烟酸、烟酸和苯甲酸的吡啶基酰胺。仅发现N-(4-吡啶基)异烟酰胺1是一种有效的水凝胶剂，其最低凝胶剂浓度为0.37 wt%。可以使用宽范围的浓度(0.37 - 20 wt%)来形成水凝胶。其他酰胺，即N-(3-吡啶基)异烟酰胺2、N-(2-吡啶基)异烟酰胺3、N-(苯基)异烟酰胺4、N-(4-吡啶基)烟酰胺5、N-(3-吡啶基)烟酰胺6和N-(4-吡啶基)苯甲酰胺7，未表现出任何凝胶化性质。已使用傅里叶变换红外光谱、变温1H NMR、单晶衍射和X射线粉末衍射(XRPD)以及扫描电子显微镜对凝胶进行表征。单晶衍射和XRPD研究表明，负责凝胶形成的形态与其块状固体和干凝胶中的形态不同。
