Hellebostad M, Ostbye K M, Halvorsen S
Department of Paediatrics, Ullevål Hospital, Oslo, Norway.
APMIS. 1992 Feb;100(2):181-7.
In order to study the role of the spleen in erythropoiesis during AKR/O leukaemogenesis, we have cultured bone marrow and spleen erythroid colony-forming units (CFU-E) and burst-forming units (BFU-E) from AKR/O mice (n = 40) with leukemia of varying severity and type of manifestation. Mice with leukaemia/lymphoma had reduced concentrations of bone marrow CFU-E and BFU-E as compared to healthy, age-matched AKR/O mice. The spleen content of CFU-E was increased, and highest in mice with a spleen size between 500 and 1000 mg. The largest spleens had a somewhat lower CFU-E content. Mice with the highest spleen CFU-E content most often had a normal PCV; however, 4/7 had a normal bone marrow CFU-E concentration. During AKR/O leukaemogenesis with development of spleen enlargement, the spleen may act as an erythropoietic organ, and contribute to maintaining a normal PCV. This may be a temporary ability which is reduced or lost with further progress of the disease.
为了研究脾脏在AKR/O白血病发生过程中对红细胞生成的作用，我们培养了来自不同严重程度和表现类型白血病的AKR/O小鼠（n = 40）的骨髓和脾脏红系集落形成单位（CFU-E）及爆式集落形成单位（BFU-E）。与健康、年龄匹配的AKR/O小鼠相比，患有白血病/淋巴瘤的小鼠骨髓CFU-E和BFU-E浓度降低。CFU-E的脾脏含量增加，在脾脏大小介于500至1000毫克的小鼠中最高。最大脾脏的CFU-E含量略低。脾脏CFU-E含量最高的小鼠大多具有正常的红细胞压积；然而，4/7的小鼠骨髓CFU-E浓度正常。在AKR/O白血病发生且脾脏肿大发展过程中，脾脏可能充当造血器官，并有助于维持正常的红细胞压积。这可能是一种随着疾病进一步发展而降低或丧失的暂时能力。
