Couturier Olivier, Chatal Jean-François, Hustinx Roland
Service de médecine nucléaire, Hôtel-Dieu, CHU, Place Alexis-Ricordeau, 44093 Nantes Cedex.
Bull Cancer. 2004 Sep;91(9):695-703.
18F-FDG is currently the only fluorinated tracer used in routine clinical positron emission tomography (PET). Fluorine 18 is considered as the ideal radioisotope for PET, thanks to a low positron energy, which not only limits the dose rate to the patients but also provides high-resolution images. Furthermore, the 110 min. physical half-life allows for high-yield radiosynthesis, transport from the production site to the imaging site, and imaging protocols that could span hours, which permits dynamic studies and assessing metabolic processes that may be fairly slow. Recently, synthesis of fluorinated tracers from prosthetic group precursors, which allows easier radiolabeling of biomolecules, has given a boost to the development of numerous fluorinated tracers. Given the wide availability of fluorine 18, such tracers may well develop into important routine tracers. This article is a review of the literature concerning fluorinated analogs of nucleosides and fluorinated radiotracers of gene expression recently developed and under investigation.
18F - FDG是目前在常规临床正电子发射断层扫描（PET）中使用的唯一氟化示踪剂。氟 - 18被认为是PET的理想放射性同位素，这得益于其低正电子能量，这不仅限制了患者所接受的剂量率，还能提供高分辨率图像。此外，110分钟的物理半衰期有利于高产率的放射性合成、从生产地点运输到成像地点以及长达数小时的成像方案，这使得动态研究以及评估可能相当缓慢的代谢过程成为可能。最近，从辅基前体合成氟化示踪剂，使得生物分子的放射性标记更加容易，这推动了众多氟化示踪剂的发展。鉴于氟 - 18的广泛可得性，此类示踪剂很可能发展成为重要的常规示踪剂。本文是一篇关于最近开发和正在研究的核苷氟化类似物以及基因表达氟化放射性示踪剂的文献综述。
