Schmidt F, Jørgensen T M, Djurhuus J C
Institute of Experimental Clinical Research, Skejby, University of Aarhus, Denmark.
Scand J Urol Nephrol Suppl. 2004(215):75-83. doi: 10.1080/03008880410015327.
To describe normal natural fill urodynamics in young men during normal and increased fluid intake.
Thirty healthy males aged 21-32 years volunteered for an ambulatory urodynamic 24 h investigation with a suprapubic catheter. The recorded micturition data were: frequency (f), voided volume (VV), voiding time, maximal flow rate (Qmax) and time to Qmax. The number of sensed and not-sensed bladder contractions, duration and time in relation to voiding were also recorded. During the recording day subjects were randomized to normal (30 ml/kg body weight per day) or larger (60 ml/kg body weight per day) fluid intake.
As expected there was a larger urine production and an increased voiding frequency in the fluid-loaded group (p<0.0001). The detrusor pressure (Pdet) Qmax was significantly higher in the fluid-loaded group (73 cmH2O, range 57-94) than in the normal fluid intake group (60 cmH2O, range 45-86) (p=0.003). No other urodynamic data differed significantly between the two groups. When comparing the ambulatory urodynamic data with previously obtained home flowmetry recordings from the same volunteers differences were only found in voiding frequency. The majority of participants had detrusor contractions, felt and unfelt, during the filling phase. Three types of detrusor activity during voiding phase could be described: type 1, with one micturition contraction, type 2, with several small contractions before micturition, and type 3, with large prolonged contractions leading to micturition.
Ambulatory urodynamics in normal young men showed a large interindividual variation. Bladder contractions during filling were frequently recorded, and premicturition contractions were consistently found. The data found in this study were similar to previous home flow recordings in the same group.
描述年轻男性在正常及增加液体摄入量时的正常自然充盈期尿动力学情况。
30名年龄在21 - 32岁的健康男性志愿者接受了一项为期24小时的动态尿动力学研究，通过耻骨上导管进行记录。记录的排尿数据包括：排尿频率（f）、排尿量（VV）、排尿时间、最大尿流率（Qmax）以及达到Qmax的时间。还记录了感知到和未感知到的膀胱收缩次数、持续时间以及与排尿相关的时间。在记录当天，受试者被随机分为正常液体摄入量组（每天每公斤体重30毫升）或较大液体摄入量组（每天每公斤体重60毫升）。
正如预期，液体负荷组的尿量产生更多，排尿频率增加（p<0.0001）。液体负荷组的逼尿肌压力（Pdet）Qmax显著高于正常液体摄入量组（液体负荷组为73 cmH₂O，范围57 - 94；正常液体摄入量组为60 cmH₂O，范围45 - 86）（p = 0.003）。两组之间的其他尿动力学数据无显著差异。将动态尿动力学数据与同一志愿者先前获得的家庭尿流率记录进行比较时，仅在排尿频率方面发现差异。大多数参与者在充盈期有逼尿肌收缩，包括可感知和不可感知的。排尿期可描述为三种逼尿肌活动类型：1型，一次排尿收缩；2型，排尿前有几次小收缩；3型，有导致排尿的大的持续性收缩。
正常年轻男性的动态尿动力学显示个体间差异较大。充盈期膀胱收缩频繁记录到，排尿前收缩也始终存在。本研究中发现的数据与同一组先前的家庭尿流记录相似。
