Ethans K D, Schryvers O I, Nance P W, Casey A R
Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Spinal Cord. 2005 Apr;43(4):214-8. doi: 10.1038/sj.sc.3101684.
The objective of this study was to evaluate the accuracy, reliability, safety, and efficacy of the Codman Model 3000 Constant Flow Implantable Infusion Pump for intrathecal baclofen delivery as a therapeutic option for the treatment of severe spasticity. The distinctive features of this pump include a raised, easily palpable septum, a safety valve protecting the bolus pathway, no programmer needed, and no battery to fail.
A total of 17 patients with spinal cord injury, multiple sclerosis, or cerebral palsy were implanted with this pump. The accuracy of the pump and drug treatment efficacy was determined at each visit and adjustments to the dosages were made as required. All the intrathecal drug delivery system complications were reviewed.
The expected efficacy was achieved. The accuracy of the implanted pumps ranged from 90-97% (average 94%). There were no complications due to primary pump problems. The complications reported are similar to other implantable infusion devices and include dehiscence of the suture line, pressure ulcer development, formation of seroma, inversion of the pump, baclofen overdose, and catheter failures.
The Codman Model 3000 Constant Flow Implantable Infusion Pump is an accurate, reliable, and convenient option for patients needing intrathecal baclofen therapy, with complications similar to other available pumps.
本研究的目的是评估Codman 3000型恒流植入式输注泵鞘内注射巴氯芬作为治疗严重痉挛的一种治疗选择的准确性、可靠性、安全性和有效性。该泵的独特特点包括一个凸起的、易于触摸到的隔膜、一个保护推注通道的安全阀、无需编程器以及没有电池故障问题。
共有17例脊髓损伤、多发性硬化症或脑瘫患者植入了该泵。每次随访时确定泵的准确性和药物治疗效果，并根据需要调整剂量。对所有鞘内药物输送系统并发症进行了回顾。
达到了预期疗效。植入泵的准确性范围为90%-97%（平均94%）。没有因泵的原发性问题而出现并发症。报告的并发症与其他植入式输注装置相似，包括缝线裂开、压疮形成、血清肿形成、泵倒置、巴氯芬过量和导管故障。
对于需要鞘内注射巴氯芬治疗的患者，Codman 3000型恒流植入式输注泵是一种准确、可靠且方便的选择，其并发症与其他现有泵相似。
