Park Jeong Wook, Kim Joong Seok, Lee Hae Kook, Kim Yeong In, Lee Kwang Soo
Department of Neurology, Catholic University of Korea, Seoul, Republic of Korea.
Headache. 2004 Nov-Dec;44(10):1005-9. doi: 10.1111/j.1526-4610.2004.04194.x.
To investigate the 5-HTT-gene-linked polymorphic region (5-HTTLPR) genotypes and harm avoidance (HA) dimension in chronic tension-type headache (CTH).
Serotonin transporter protein (5-HTT) is a key modulating protein in synaptic serotonergic neurotransmission. Among serotonin gene-linked polymorphism, promoter located in the regulatory region of the 5-HTTLPR has two alleles (short and long) with different transcriptional efficiencies. The HA personality trait may be heritable and associated with serotonergic neurotransmitter activity.
We amplified the 5-HTTLPR by means of polymerase chain reaction and performed genotype polymorphism analyses and we investigated the serotonin-related personality trait by evaluating the HA dimension in tridimensional personality questionnaire (TPQ) in 107 patients with CTH and in 100 healthy controls.
We found an excess frequency of the short allele and a different genotype distribution in patients with CTH. S/S genotype frequency was significantly higher in patients with CTH (76%) than in those with controls (59%; P=.02). Patients with CTH had significantly higher HA scores (21.4+/6.3) than controls (16.3+/-6.1).
This suggests a serotonergic activity might be involved in the development of CTH and 5-HTTLPR might be one of the genetically contributing factors.
研究慢性紧张型头痛（CTH）患者的5-羟色胺转运体基因相关多态性区域（5-HTTLPR）基因型与回避伤害（HA）维度。
5-羟色胺转运体蛋白（5-HTT）是突触5-羟色胺能神经传递中的关键调节蛋白。在5-羟色胺基因相关多态性中，位于5-HTTLPR调控区的启动子有两个等位基因（短和长），转录效率不同。HA人格特质可能具有遗传性，并与5-羟色胺能神经递质活性有关。
我们通过聚合酶链反应扩增5-HTTLPR并进行基因型多态性分析，通过评估107例CTH患者和100例健康对照者三维人格问卷（TPQ）中的HA维度来研究与5-羟色胺相关的人格特质。
我们发现CTH患者中短等位基因频率过高且基因型分布不同。CTH患者的S/S基因型频率（76%）显著高于对照组（59%；P=0.02）。CTH患者的HA得分（21.4±6.3）显著高于对照组（16.3±6.1）。
这表明5-羟色胺能活性可能参与了CTH的发病过程，5-HTTLPR可能是遗传致病因素之一。
