Maitland K, Bunce M, Harding R M, Barnardo M C N M, Clegg J B, Welsh K, Bowden D K, Williams T N
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
Tissue Antigens. 2004 Dec;64(6):678-86. doi: 10.1111/j.1399-0039.2004.00328.x.
HLA class-I and class-II allele frequencies and two-locus haplotypes were examined in 367 unrelated Melanesians living on the islands of Vanuatu and New Caledonia. Diversity at all HLA class-I and class-II loci was relatively limited. In class-I loci, three HLA-A allelic groups (HLA-A24, HLA-A34 and HLA-A11), seven HLA-B alleles or allelic groups (HLA-B1506, HLA-B5602, HLA-B13, HLA-B5601, HLA-B4001, HLA-B4002 and HLA-B2704) and four HLA-C alleles or allelic groups (HLA-Cw04, HLA-Cw01, HLA-Cw0702 and HLA-Cw15) constituted more than 90% of the alleles observed. In the class-II loci, four HLA-DRB1 alleles (HLA-DRB115, HLA-DRB111, HLA-DRB104 and HLA-DRB116), three HLA-DRB3-5 alleles (HLA-DRB302, HLA-DRB401 and HLA-DRB501/02) and five HLA-DQB1 alleles (HLA-DQB10301, HLA-DQB104, HLA-DQB105, HLA-DQB10601 and HLA-DQB10602) constituted over 93, 97 and 98% of the alleles observed, respectively. Homozygosity showed significant departures from expected levels for neutrality based on allele frequency (i.e. excess diversity) at the HLA-B, HLA-Cw, HLA-DQB1 and HLA-DRB3/5 loci on some islands. The locus with the strongest departure from neutrality was HLA-DQB1, homozygosity being significantly lower than expected on all islands except New Caledonia. No consistent pattern was demonstrated for any HLA locus in relation to malaria endemicity.
对生活在瓦努阿图和新喀里多尼亚岛屿上的367名无亲缘关系的美拉尼西亚人进行了HLA I类和II类等位基因频率以及两位点单倍型的检测。所有HLA I类和II类基因座的多样性相对有限。在I类基因座中，三个HLA - A等位基因组（HLA - A24、HLA - A34和HLA - A11）、七个HLA - B等位基因或等位基因组（HLA - B1506、HLA - B5602、HLA - B13、HLA - B5601、HLA - B4001、HLA - B4002和HLA - B2704）以及四个HLA - C等位基因或等位基因组（HLA - Cw04、HLA - Cw01、HLA - Cw0702和HLA - Cw15）构成了所观察到的等位基因的90%以上。在II类基因座中，四个HLA - DRB1等位基因（HLA - DRB115、HLA - DRB111、HLA - DRB104和HLA - DRB116）、三个HLA - DRB3 - 5等位基因（HLA - DRB302、HLA - DRB401和HLA - DRB501/02）以及五个HLA - DQB1等位基因（HLA - DQB10301、HLA - DQB104、HLA - DQB105、HLA - DQB10601和HLA - DQB10602）分别构成了所观察到的等位基因的93%、97%和98%以上。在一些岛屿上，基于等位基因频率，HLA - B、HLA - Cw、HLA - DQB1和HLA - DRB3/5基因座的纯合性显示出与预期中性水平的显著偏差（即多样性过剩）。偏离中性最强的基因座是HLA - DQB1，除新喀里多尼亚外，在所有岛屿上其纯合性均显著低于预期。关于疟疾流行情况，任何HLA基因座均未表现出一致的模式。
