Bogdan Christian, Mattner Jochen, Schleicher Ulrike
Institute of Medical Microbiology and Hygiene, Department of Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.
Immunol Rev. 2004 Dec;202:33-48. doi: 10.1111/j.0105-2896.2004.00207.x.
For a long time, the family of type I interferons (IFN-alpha/beta) has received little attention outside the fields of virology and tumor immunology. In recent years, IFN-alpha/beta regained the interest of immunologists, due to the phenotypic and functional characterization of IFN-alpha/beta-producing cells, the definition of novel immunomodulatory functions and signaling pathways of IFN-alpha/beta, and the observation that IFN-alpha/beta not only exerts antiviral effects but is also relevant for the pathogenesis or control of certain bacterial and protozoan infections. This review summarizes the current knowledge on the production and function of IFN-alpha/beta during non-viral infections in vitro and in vivo.
长期以来，I型干扰素（IFN-α/β）家族在病毒学和肿瘤免疫学领域之外很少受到关注。近年来，由于产生IFN-α/β的细胞的表型和功能特征、IFN-α/β新的免疫调节功能和信号通路的定义，以及IFN-α/β不仅具有抗病毒作用而且与某些细菌和原生动物感染的发病机制或控制相关的观察结果，IFN-α/β重新引起了免疫学家的兴趣。本综述总结了目前关于体外和体内非病毒感染期间IFN-α/β的产生和功能的知识。
