通过伴侣-导路途径进行的纤维组装。

Fiber assembly by the chaperone-usher pathway.

作者信息

Sauer Frederic G, Remaut Han, Hultgren Scott J, Waksman Gabriel

机构信息

Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave., New Haven, CT 06536, USA.

出版信息

Biochim Biophys Acta. 2004 Nov 11;1694(1-3):259-67. doi: 10.1016/j.bbamcr.2004.02.010.

DOI:10.1016/j.bbamcr.2004.02.010

PMID:15546670

Abstract

Bacterial pathogens utilize the chaperone-usher pathway to assemble extracellular multi-subunit fibers essential for virulence. The periplasmic chaperone facilitates the initial folding of fiber subunits but then traps them in activated folding transition states. Chaperone dissociation releases the folding energy that drives subunit incorporation into the fiber, which grows through a pore formed by the outer-membrane usher.

摘要

细菌病原体利用伴侣-外膜蛋白途径组装对毒力至关重要的细胞外多亚基纤维。周质伴侣促进纤维亚基的初始折叠，但随后将它们捕获在活化的折叠过渡态中。伴侣解离释放驱动亚基掺入纤维的折叠能量，纤维通过外膜外膜蛋白形成的孔生长。