Shindo Kazutoshi, Osawa Ayako, Nakamura Ryoko, Kagiyama Yukiko, Sakuda Shohei, Shizuri Yoshikazu, Furukawa Kensuke, Misawa Norihiko
Department of Food and Nutrition, Japan Women's University, 2-8-1, Mejirodai, Bunkyo-ku, Tokyo 112-8681, Japan.
J Am Chem Soc. 2004 Nov 24;126(46):15042-3. doi: 10.1021/ja044850g.
The comprehensive bioconversion of aromatic compounds with a benzene ring to a picolinic acid was achieved with a recombinant Escherichia coli strain that expressed the six genes involved in biphenyl catabolism, these being the bphA1(2072)A2A3A4 genes encoding the evolved biphenyl dioxygenase, the bphB gene encoding dihydrodiol dehydrogenase, and the bphC gene encoding catechol 2,3-dioxygenase.