Burnstock Geoffrey, Knight Gillian E
Autonomic Neuroscience Institute, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.
Int Rev Cytol. 2004;240:31-304. doi: 10.1016/S0074-7696(04)40002-3.
This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body. Each section provides an account of the early history of purinergic signaling in the organ?cell up to 1994, then summarizes subsequent evidence for the presence of P2X and P2Y receptor subtype mRNA and proteins as well as functional data, all fully referenced. A section is included describing the plasticity of expression of P2 receptors during development and aging as well as in various pathophysiological conditions. Finally, there is some discussion of possible future developments in the purinergic signaling field.
本综述旨在为读者提供一篇关于P2受体在人体所有器官、组织和细胞中的分布及功能的全面参考文章。每一部分都介绍了截至1994年该器官或细胞中嘌呤能信号传导的早期历史，然后总结了随后关于P2X和P2Y受体亚型mRNA和蛋白质存在的证据以及功能数据，所有这些都有充分的参考文献。其中包括一部分内容，描述了P2受体在发育、衰老以及各种病理生理条件下表达的可塑性。最后，对嘌呤能信号传导领域未来可能的发展进行了一些讨论。
