变应性角结膜炎刷片细胞学样本中的炎性细胞与角膜病变的严重程度相关。
Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis.
作者信息
Takano Y, Fukagawa K, Dogru M, Asano-Kato N, Tsubota K, Fujishima H
机构信息
Department of Ophthalmology, Kawasaki Municipal Hospital, 12-1 Shinkawa-dori, Kawasaki-ku, Kawasaki-shi, Kanagawa, Japan 210-0013.
出版信息
Br J Ophthalmol. 2004 Dec;88(12):1504-5. doi: 10.1136/bjo.2004.047167.
BACKGROUND
Inflammatory cells infiltrating to the tarsal conjunctiva are thought to be involved in the pathogenesis of corneal lesions in severe allergic conjunctival diseases. The relation between such cells and the severity of corneal lesions was studied.
METHODS
Six patients with atopic keratoconjunctivitis (AKC) were enrolled in this study. Tarsal brush cytology findings and the severity of corneal damage at that point were recorded and analysed for correlation.
RESULTS
Four out of six patients exhibited correlation between eosinophils and corneal damage. Three out of six patients exhibited correlation between neutrophils and corneal damage. Two out of six patients exhibited correlation between both eosinophils and neutrophils and corneal damage. Analysis of all data from all patients taken together revealed that both eosinophils and neutrophils in brush cytology samples significantly correlated with corneal damage.
CONCLUSIONS
Inflammatory cells in brush cytology samples correlated with corneal damage. Evaluation of the relative percentages of inflammatory cells in brush cytology samples is a useful method of assessing disease activity in allergic conjunctival disease.
背景
浸润睑结膜的炎性细胞被认为参与了严重过敏性结膜疾病中角膜病变的发病机制。研究了此类细胞与角膜病变严重程度之间的关系。
方法
本研究纳入了6例特应性角结膜炎（AKC）患者。记录睑结膜刷片细胞学检查结果以及当时角膜损伤的严重程度，并分析两者之间的相关性。
结果
6例患者中有4例显示嗜酸性粒细胞与角膜损伤之间存在相关性。6例患者中有3例显示中性粒细胞与角膜损伤之间存在相关性。6例患者中有2例显示嗜酸性粒细胞和中性粒细胞均与角膜损伤之间存在相关性。对所有患者的所有数据进行综合分析发现，刷片细胞学样本中的嗜酸性粒细胞和中性粒细胞均与角膜损伤显著相关。
结论
刷片细胞学样本中的炎性细胞与角膜损伤相关。评估刷片细胞学样本中炎性细胞的相对百分比是评估过敏性结膜疾病疾病活动度的一种有用方法。
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