Şimşek Cem, Kojima Takashi, Doğru Murat
Muğla Sıtkı Koçman University Faculty of Medicine, Department of Ophthalmology, Muğla, Türkiye.
Keio University Faculty of Medicine, Department of Ophthalmology, Tokyo, Japan.
Turk J Ophthalmol. 2024 Dec 31;54(6):344-353. doi: 10.4274/tjo.galenos.2024.49769.
In vivo confocal microscopy (IVCM) is a non-invasive imaging technique used to visualize the layers of the cornea and conjunctiva in real time. In patients with atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC), this technology can be useful in diagnosing and monitoring the disease, as well as evaluating the efficacy of treatments. IVCM can reveal subclinical abnormalities in the corneal and conjunctival epithelium such as inflammatory cell infiltrates and tissue damage, which can provide insight into the pathogenesis of AKC. In AKC, IVCM reveals changes around the conjunctival papillae, inflammatory cells around punctate defects in the corneal epithelium, changes in subbasal nerve morphology, and deteriorations in the goblet cells in the meibomian gland are observed. In VKC, alterations can be observed in the diameter, brightness and nucleus/cytoplasm ratio of the superficial epithelial cells in the cornea. The use of IVCM in AKC and VKC can therefore aid in the early detection and management of the disease, as well as contribute to a better understanding of its underlying mechanisms.
共聚焦显微镜活体检查（IVCM）是一种非侵入性成像技术，用于实时观察角膜和结膜各层。对于患有特应性角结膜炎（AKC）和春季角结膜炎（VKC）的患者，该技术在疾病诊断、监测以及评估治疗效果方面可能有用。IVCM可以揭示角膜和结膜上皮的亚临床异常，如炎性细胞浸润和组织损伤，这有助于深入了解AKC的发病机制。在AKC中，IVCM显示结膜乳头周围的变化、角膜上皮点状缺损周围的炎性细胞、基底神经形态的变化以及睑板腺杯状细胞的退化。在VKC中，可以观察到角膜表面上皮细胞的直径、亮度和核质比的改变。因此，IVCM在AKC和VKC中的应用有助于疾病的早期检测和管理，也有助于更好地理解其潜在机制。
