Rajagopalan Harith, Lengauer Christoph
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA.
Nature. 2004 Nov 18;432(7015):338-41. doi: 10.1038/nature03099.
In contrast to normal cells, aneuploidy--alterations in the number of chromosomes--is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.
与正常细胞不同，非整倍体——染色体数量的改变——在几乎所有癌症中都持续存在。越来越多的证据表明，非整倍体通常由一种特定类型的基因不稳定导致，这种不稳定被称为染色体不稳定，它可能反映了癌细胞有丝分裂分离过程中的缺陷。更好地理解导致非整倍体的分子机制有望开发出针对这一过程的癌症药物。
