Frediani F
Neurological Department, Policlinico S. Pietro, Via Forlanini 15, I-24036 Ponte S. Pietro (BG), Italy.
Neurol Sci. 2004 Oct;25 Suppl 3:S161-6. doi: 10.1007/s10072-004-0278-4.
Anticonvulsant drugs have been used in migraine prophylaxis since 1970. In recent years, new antiepileptic medications have given rise to much interest in pain control. Primary headaches prophylaxis is still based on old drugs, and physicians facing these conditions are always prompted to use any new possible choice. Among primary headaches, the most studied drug over last 15 years was divalproex sodium, and many papers showed its efficacy in the treatment of migraine headaches. Valproate is well tolerated and many dosages have been used with success. For the newer drugs, such as gabapentin, lamotrigine or topiramate, evidence is less strong but has been rapidly increasing in the last 5 years. In particular, topiramate has much more evidence of a good efficacy and a safe profile. We review the principal characteristics of their use, according to dosages, lasting of treatments, side effects and significant efficacy.
自1970年以来，抗惊厥药物一直用于偏头痛的预防。近年来，新型抗癫痫药物引起了人们对疼痛控制的极大兴趣。原发性头痛的预防仍然基于老药，面对这些情况的医生总是被促使使用任何新的可能选择。在原发性头痛中，过去15年研究最多的药物是丙戊酸钠，许多论文表明其在治疗偏头痛方面的疗效。丙戊酸盐耐受性良好，许多剂量的使用都取得了成功。对于较新的药物，如加巴喷丁、拉莫三嗪或托吡酯，证据不太充分，但在过去5年中迅速增加。特别是，托吡酯有更多证据表明其疗效良好且安全性高。我们根据剂量、治疗持续时间、副作用和显著疗效回顾了它们使用的主要特点。
