Bizzarro Matthew J, Gross Ian
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, Children's Hospital WP 493, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-8064, USA.
Obstet Gynecol Clin North Am. 2004 Dec;31(4):949-61, xii. doi: 10.1016/j.ogc.2004.08.001.
Endogenous hormones, such as glucocorticoids, play a major role in the development of the fetal lung. Considerable effort has been devoted to defining the underlying physiology and the clinical effects of administration of antenatal glucocorticoids to women who are at risk of premature delivery. Antenatal glucocorticoids have significant therapeutic benefits to the neonate with respect to the respiratory distress syndrome, intraventricular hemorrhage, and mortality. Current controversies relate to the choice of glucocorticoid, optimal dosing regime, number of courses of therapy that should be administered, and, most importantly, potential toxicities.
内源性激素，如糖皮质激素，在胎儿肺发育中起主要作用。人们已经付出了相当大的努力来确定其潜在的生理学机制以及对有早产风险的妇女给予产前糖皮质激素的临床效果。产前糖皮质激素在呼吸窘迫综合征、脑室内出血和死亡率方面对新生儿有显著的治疗益处。目前的争议涉及糖皮质激素的选择、最佳给药方案、应给予的治疗疗程数，以及最重要的潜在毒性。
