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Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus: reanalysis of West African studies.高滴度麻疹疫苗接种后男女死亡率差异及其与随后白喉-破伤风-百日咳和灭活脊髓灰质炎病毒疫苗接种的关联：西非研究的重新分析
Lancet. 2003 Jun 28;361(9376):2183-8. doi: 10.1016/S0140-6736(03)13771-3.
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Commentary: an unexpected finding that needs confirmation or rejection.评论：一项需要证实或证伪的意外发现。
BMJ. 2000 Dec 9;321(7274):1439.
3
Routine vaccinations and child survival: follow up study in Guinea-Bissau, West Africa.常规疫苗接种与儿童生存：西非几内亚比绍的随访研究
BMJ. 2000 Dec 9;321(7274):1435-8. doi: 10.1136/bmj.321.7274.1435.
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Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries.麻疹免疫接种的非特异性有益效果：对发展中国家死亡率研究的分析
BMJ. 1995 Aug 19;311(7003):481-5. doi: 10.1136/bmj.311.7003.481.
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Measles mortality and vaccine efficacy in rural West Africa.西非农村地区的麻疹死亡率与疫苗效力
Lancet. 1983 Apr 30;1(8331):972-5. doi: 10.1016/s0140-6736(83)92091-3.
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Impact of measles vaccination on childhood mortality in rural Bangladesh.麻疹疫苗接种对孟加拉国农村地区儿童死亡率的影响。
Bull World Health Organ. 1990;68(4):441-7.

疫苗接种对儿童生存的非特异性影响：布基纳法索的前瞻性队列研究

Non-specific effects of vaccination on child survival: prospective cohort study in Burkina Faso.

作者信息

Vaugelade J, Pinchinat S, Guiella G, Elguero E, Simondon F

机构信息

Institut de Recherche pour le Développement, Laboratoire Population, Environnement et Développement, BP 64501, 34394 Montpellier Cedex 5, France.

出版信息

BMJ. 2004 Dec 4;329(7478):1309. doi: 10.1136/bmj.38261.496366.82. Epub 2004 Nov 18.

DOI:10.1136/bmj.38261.496366.82
PMID:15550402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC534835/
Abstract

OBJECTIVE

To study the effect of vaccination on mortality before 2 years of age in a developing country.

DESIGN

Prospective cohort study.

SETTING

Rural communities in Burkina Faso.

PARTICIPANTS

9085 children born in the study area between 1985 and 1993.

MAIN OUTCOME MEASURE

Child death rate.

RESULTS

Mortality before 2 years of age was lower in children who had been vaccinated: those vaccinated with BCG only had significantly lower mortality (risk ratio for vaccinated v unvaccinated children 0.37, 95% confidence interval 0.29 to 0.48) as did those vaccinated with diphtheria, tetanus, and pertussis only (0.24, 0.13 to 0.43). The second dose of diphtheria, tetanus, and pertussis was not associated with lower mortality (0.80, 0.58 to 1.12).

CONCLUSION

Vaccination with diphtheria, tetanus, and pertussis as well as BCG is associated with better survival of children up to 2 years of age.

摘要

目的

研究在一个发展中国家接种疫苗对2岁前儿童死亡率的影响。

设计

前瞻性队列研究。

地点

布基纳法索的农村社区。

参与者

1985年至1993年在研究地区出生的9085名儿童。

主要观察指标

儿童死亡率。

结果

接种疫苗的儿童2岁前死亡率较低：仅接种卡介苗的儿童死亡率显著较低（接种疫苗儿童与未接种疫苗儿童的风险比为0.37，95%置信区间为0.29至0.48），仅接种白喉、破伤风和百日咳疫苗的儿童也是如此（0.24，0.13至0.43）。白喉、破伤风和百日咳疫苗的第二剂与较低死亡率无关（0.80，0.58至1.12）。

结论

接种白喉、破伤风和百日咳疫苗以及卡介苗与2岁以下儿童更好的存活率相关。