Yoshimasu Tatsuya, Sasaki Rie, Oura Shoji, Hirai Issei, Kokawa Yozo, Tanino Hirokazu, Sakurai Teruhisa, Okamura Yoshitaka
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan.
Breast Cancer. 2004;11(2):203-5. doi: 10.1007/BF02968302.
Carcinoembryonic antigen (CEA) elimination kinetics after tumor resection were measured in a case of breast cancer. A 45-year-old woman with a left breast carcinoma underwent surgery after neoadjuvant chemotherapy. The serum CEA level before surgery was 34.3 ng/ml. After sequential monitoring of serum CEA levels, postoperative serum CEA elimination kinetics were calculated using non-linear least square analysis with the fitting equation C(t)=(C0-Cp)exp(-kt)+Cp, where C(t) was the postoperative CEA level, t was the number days after surgery, C0 was the CEA level at postoperative time zero, Cp was the CEA at plateau, and k was the rate constant of elimination. Cp was calculated as 6.9 ng/ml, which was above the cut-off level and indicated residual malignancy. After adjuvant chemotherapy, CEA normalized to 1.8 ng/ml. In breast cancer patients with high preoperative serum CEA levels, our analytical method for CEA elimination might be useful for the detection of residual malignancies.
在一例乳腺癌患者中测量了肿瘤切除后癌胚抗原（CEA）的清除动力学。一名45岁左乳腺癌女性在新辅助化疗后接受了手术。术前血清CEA水平为34.3 ng/ml。在对血清CEA水平进行连续监测后，使用拟合方程C(t)=(C0-Cp)exp(-kt)+Cp通过非线性最小二乘法分析计算术后血清CEA清除动力学，其中C(t)为术后CEA水平，t为术后天数，C0为术后时间零时的CEA水平，Cp为平台期CEA水平，k为清除速率常数。计算得出Cp为6.9 ng/ml，高于临界值，提示存在残留恶性肿瘤。辅助化疗后，CEA恢复正常至1.8 ng/ml。对于术前血清CEA水平较高的乳腺癌患者，我们的CEA清除分析方法可能有助于检测残留恶性肿瘤。
