Schaible Ulrich E, Kaufmann Stefan H E
Max-Planck-Institute for Infection Biology, Department of Immunology, Schumannstrasse 21-22, D-10117, Berlin, Germany.
Nat Rev Microbiol. 2004 Dec;2(12):946-53. doi: 10.1038/nrmicro1046.
The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. It is also a pivotal component of the innate immune response through its role in the generation of toxic oxygen and nitrogen intermediates. During evolution, the shared requirement of micro- and macroorganisms for this important nutrient has shaped the pathogen-host relationship. Here, we discuss how pathogens compete with the host for iron, and also how the host uses iron to counteract this threat.
铁作为基本代谢途径中的辅助因子，对致病微生物及其宿主而言均至关重要。它在有毒氧和氮中间体的生成过程中发挥作用，也是先天免疫反应的关键组成部分。在进化过程中，微生物和宏观生物对这种重要营养素的共同需求塑造了病原体与宿主之间的关系。在此，我们将探讨病原体如何与宿主争夺铁，以及宿主如何利用铁来对抗这种威胁。
