Pascual J C, Fleisher A B
Department of Dermatology, Hospital General de Alicantem, Alicante, Spain.
Skin Therapy Lett. 2004 Nov;9(9):1-5.
Tacrolimus ointment (Protopic, Fujisawa) is an effective agent in a class of topical immunomodulators. Its mechanism of action is based on calcineurin inhibition, which results in decreased T-cell activation and inflammatory cytokine release. Tacrolimus ointment is safe and effective for short- and long-term treatment of atopic dermatitis (AD) in pediatric and adult patients. The most common adverse events associated with its use are a transient burning sensation and pruritus at the site of application. Unlike topical corticosteroid agents, tacrolimus ointment does not cause a reduction in collagen synthesis or skin thickness. Because tacrolimus ointment does not cause skin atrophy, it may be safely used for months or years on all skin areas, including the face and intertriginous areas.
他克莫司软膏（普特彼，藤泽公司）是一类局部免疫调节剂中的有效药物。其作用机制基于对钙调神经磷酸酶的抑制，这会导致T细胞活化及炎性细胞因子释放减少。他克莫司软膏对于儿童和成人患者特应性皮炎（AD）的短期和长期治疗均安全有效。与其使用相关的最常见不良事件是用药部位出现短暂的烧灼感和瘙痒。与局部皮质类固醇药物不同，他克莫司软膏不会导致胶原蛋白合成减少或皮肤厚度降低。由于他克莫司软膏不会引起皮肤萎缩，因此可在包括面部和间擦部位在内的所有皮肤区域安全使用数月或数年。
