Belshe Robert B, Newman Frances K, Anderson Edwin L, Wright Peter F, Karron Ruth A, Tollefson Sharon, Henderson Frederick W, Meissner H Cody, Madhi Shabir, Roberton Don, Marshall Helen, Loh Richard, Sly Peter, Murphy Brian, Tatem Joanne M, Randolph Valerie, Hackell Jill, Gruber William, Tsai Theodore F
Saint Louis University, St. Louis, Missouri 63110, USA.
J Infect Dis. 2004 Dec 15;190(12):2096-103. doi: 10.1086/425981. Epub 2004 Nov 8.
We evaluated a combination respiratory syncytial virus (RSV) and parainfluenza 3 virus (PIV3) live, attenuated intranasal vaccine for safety, viral replication, and immunogenicity in doubly seronegative children 6-18 months old. RSV cpts-248/404 and PIV3-cp45 vaccines were combined in a dose of 10(5) plaque-forming units of each per 0.5-mL dose and compared with monovalent vaccines or placebo. The virus shedding pattern of RSV was not different between monovalent RSV cpts-248/404 vaccine and combination vaccine. Modest reductions in the shedding of PIV3-cp45 vaccine virus were found after the administration of RSV cpts-248/404 and PIV3-cp45 vaccine, relative to monovalent PIV3 vaccine; 16 (76%) of 21 children given combination vaccine shed PIV3-cp45 versus 11 (92%) of 12 of those given monovalent PIV3 vaccine. Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/PV3 vaccine is feasible for simultaneous administration, and further studies are warranted.
我们评估了一种呼吸道合胞病毒（RSV）和副流感3型病毒（PIV3）的联合减毒活鼻内疫苗，用于6至18个月大的双血清阴性儿童的安全性、病毒复制及免疫原性。RSV cpts-248/404疫苗和PIV3-cp45疫苗按每0.5毫升剂量各含10(5)个空斑形成单位的剂量组合，并与单价疫苗或安慰剂进行比较。单价RSV cpts-248/404疫苗和联合疫苗之间RSV的病毒排出模式没有差异。相对于单价PIV3疫苗，在接种RSV cpts-248/404和PIV3-cp45联合疫苗后，发现PIV3-cp45疫苗病毒的排出有适度减少；21名接种联合疫苗的儿童中有16名（76%）排出PIV3-cp45，而接种单价PIV疫苗的12名儿童中有11名（92%）排出。两种疫苗均具有免疫原性，单价组和联合组之间的抗体反应相似。联合RSV/PV3疫苗同时接种是可行的，有必要进行进一步研究。
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