Tatomirović Zeljka, Bokun Radojka, Skuletić Vesna, Ilić Srbislav, Roganović Branka, Milutinović Dragan
Vojnomedicinska akademija, ZPSM-Institut za patologiju, Beograd, Srbija i Crna Gora.
Vojnosanit Pregl. 2004 Sep-Oct;61(5):561-4. doi: 10.2298/vsp0405561t.
Sister Mary Joseph's nodule is the eponym for metastatic involvement of the umbilicus. This less common entity is the sign of disseminated malignant disease, mainly of digestive and gynecologic origin, and is associated with a poor prognosis. A case of Sister Mary Joseph's nodule in a 76-year-old woman in whom the umbilical metastasis was the first sign of malignant disease in presented. The diagnosis of metastatic adenocarcinoma was established by fine needle aspiration cytology of the umbilical nodule. Radiological and ultrasonographic investigation disclosed carcinoma of the gallbladder with pancreas, stomach, and colon invasion as well as peritoneal dissemination. The diagnosis was confirmed by exploratory laparatomy and histological examination of the excised umbilical nodule.
玛丽·约瑟夫修女结节是脐部转移受累的代名词。这种不太常见的情况是播散性恶性疾病的体征,主要起源于消化和妇科系统,且预后较差。本文报道了一例76岁女性的玛丽·约瑟夫修女结节病例,其中脐部转移是恶性疾病的首发体征。通过脐部结节细针穿刺细胞学检查确诊为转移性腺癌。影像学和超声检查发现胆囊癌侵犯胰腺、胃和结肠以及腹膜播散。通过剖腹探查术和对切除的脐部结节进行组织学检查证实了诊断。