Bilar Marek
Z Kliniki Medycyny Matczyno-Płodowej Pomorskiej Akademii Medycznej w Szczecinie, ul. Unii Lubelskiej 1, 71-252 Szczecin.
Ann Acad Med Stetin. 2003;49:173-92.
The present study was designed to analyze retrospectively the course of 2693 pregnancies and deliveries between 1999 and 2000 at the Department of Pathology of Pregnancy and Labor, Pomeranian Academy of Medicine in Szczecin. Attention was focused on the frequency of cesarean sections including preventive and urgent cases, obstetric and paraobstetric pathologies complicating pregnancy, perinatal and maternal mortality. The efficacy of diagnosing fetal distress in pregnancy and labor by continuous fetal monitoring with cardiotocography versus ultrasonography, in particular umbilical artery Doppler velocimetry, was studied. The material consisted of 2693 pregnant women (1476 (54.8%) primiparous and 1217 (45.2%) multiparous) aged 15-46 years, and their 2802 newborns. Gestational age varied between 23 and 43 weeks. Two groups were formed: I--1268 women delivering by cesarean section between 1991 and 1995; II--1425 women delivering by cesarean section between 1996 and 2000. In 1995/1996, complete ultrasonography supplemented with umbilical artery Doppler flow and intrauterine invasive intervention (cordocentesis, amnioinfusion, amnioreduction, intrauterine fetal blood transfusion) were introduced, as well as screening for diabetes in pregnancy and immunological tests for anticardiolipin antibodies. At that time, the Program of Improved Prenatal Care in Poland was fully implemented. Moreover, the Intensive Therapy of Newborns Uni was established at the Department of Pathology of Pregnancy and Labor. Depending on the moment the decision to perform cesarean section was taken, the prospective group was divided into two groups: antenatal (group P--1036 gravida) and intranatal (group S--1657 parturients). Depending on indications for cesarean section, urgent (N) were distinguished from preventive (Pr) cases. CTG interpretation was performe using qualitative and semi-quantitative Fischer's method. CTG recordings during labor were interpreted according to the qualitative method proposed by FIGO in 1987. An analysis of PI, S/D, RI, and flow curve (absence (AEDF) or reversion (REDF) of end-diastolic umbilical artery blood flow) in umbilical artery Doppler velocimetr was performed. A decrease of more than two standard deviations from average valu for several pregnancy time intervals was regarded as pathological. The absence (AEDF) or reversion (REDF) of end-diastolic umbilical artery blood flow was considered to be a high risk factor. The status of newborns was assessed using 5 min Apgar score and parameters o acid-base equilibrium in umbilical artery blood. The following conclusions were drawn: 1. Analysis of cases during the last decade of the 20th century revealed: --increased rate of cesarean sections with a shift in indications from urgent to preventive; --increase in obstetric risk associated with higher percentage of complication during pregnancy; --higher percentage of cesarean sections in premature labor; --correlation between premature labor and increased risk of poor newborn statu --decrease in perinatal mortality of newborns. 2. Analysis of methods for antepartum fetal monitoring revealed: --abnormal CTG patterns and abnormal blood flow in umbilical artery with ab sence or reversion of end-diastolic blood flow the coexistence of which were diagnostically effective for prediction of poor newborn status. 3. Analysis of fetal monitoring methods revealed: --normal intrapartum CTG patterns and normal antepartum blood flow in umbilical artery were markers of good newborn status; --abnormal CTG patterns and abnormal blood flow in umbilical artery had lim ited predictive value regarding poor newborn status. 4. Evolution of indications for cesarean section was multifactorial in character. New and more effective methods for fetal monitoring are needed.
本研究旨在回顾性分析1999年至2000年期间在什切青波美拉尼亚医学院妊娠与分娩病理科的2693例妊娠和分娩过程。重点关注剖宫产的频率,包括预防性和紧急情况、妊娠合并的产科和产科外病理情况、围产期和孕产妇死亡率。研究了通过胎心监护仪持续胎儿监测与超声检查,特别是脐动脉多普勒测速法,在妊娠和分娩中诊断胎儿窘迫的有效性。材料包括2693名年龄在15至46岁之间的孕妇(1476例(54.8%)初产妇和1217例(45.2%)经产妇)及其2802名新生儿。孕周在23至43周之间。分为两组:I组——1991年至1995年期间剖宫产分娩的1268名妇女;II组——1996年至2000年期间剖宫产分娩的1425名妇女。1995/1996年,引入了完整的超声检查,辅以脐动脉多普勒血流和宫内侵入性干预(脐静脉穿刺、羊膜腔灌注、羊水减量、宫内胎儿输血),以及妊娠糖尿病筛查和抗心磷脂抗体免疫检测。当时,波兰改进产前护理计划全面实施。此外,妊娠与分娩病理科成立了新生儿重症治疗单元。根据决定进行剖宫产的时间,前瞻性组分为两组:产前(P组——1036名孕妇)和产时(S组——1657名产妇)。根据剖宫产指征,区分紧急(N)和预防性(Pr)病例。采用定性和半定量的费舍尔方法进行胎心监护解释。分娩期间的胎心监护记录根据国际妇产科联合会1987年提出的定性方法进行解释。对脐动脉多普勒测速中的搏动指数(PI)、收缩期/舒张期比值(S/D)、阻力指数(RI)和血流曲线(舒张末期脐动脉血流缺失(AEDF)或逆转(REDF))进行分析。几个妊娠时间间隔内较平均值下降超过两个标准差被视为病理性。舒张末期脐动脉血流缺失(AEDF)或逆转(REDF)被认为是高危因素。使用5分钟阿氏评分和脐动脉血酸碱平衡参数评估新生儿状况。得出以下结论:1. 对20世纪最后十年病例的分析显示:——剖宫产率上升,指征从紧急转向预防性;——与妊娠期间更高的并发症百分比相关的产科风险增加;——早产中剖宫产的百分比更高;——早产与新生儿不良状况风险增加之间的相关性;——新生儿围产期死亡率下降。2. 对产前胎儿监测方法的分析显示:——异常的胎心监护模式和脐动脉血流异常,伴有舒张末期血流缺失或逆转,两者共存对预测新生儿不良状况具有诊断有效性。3. 对胎儿监测方法的分析显示:——产时正常的胎心监护模式和产前脐动脉血流正常是新生儿状况良好的标志;——异常的胎心监护模式和脐动脉血流异常对新生儿不良状况的预测价值有限。4. 剖宫产指征的演变具有多因素性质。需要新的、更有效的胎儿监测方法。