[钆-AAZTA]-：新一代改进型磁共振成像造影剂的一种新结构类型。

[Gd-AAZTA]-: a new structural entry for an improved generation of MRI contrast agents.

作者信息

Aime Silvio, Calabi Luisella, Cavallotti Camilla, Gianolio Eliana, Giovenzana Giovanni B, Losi Pietro, Maiocchi Alessandro, Palmisano Giovanni, Sisti Massimo

机构信息

Dipartimento di Chimica IFM, Università degli Studi di Torino, Via P. Giuria 7, I-10125 Torino, Italy.

出版信息

Inorg Chem. 2004 Nov 29;43(24):7588-90. doi: 10.1021/ic0489692.

DOI:10.1021/ic0489692

PMID:15554621

Abstract

An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.

摘要

本文描述了一种基于前所未有的且易于获得的配体AAZTA的创新型磁共振成像（MRI）造影剂。报道了该配体简单直接的合成方法，以及相应钆（III）螯合物的电位滴定和弛豫行为。配合物[Gd(AAZTA)]-表现出卓越的磁性能，在水溶液中具有高热力学稳定性，并且对双齿内源性阴离子的影响几乎完全惰性，使其成为开发高性能MRI造影剂最有前景的候选物之一。