Plouffe Joseph F, Martin Daniel R
Department of Internal Medicine, Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA.
Infect Dis Clin North Am. 2004 Dec;18(4):963-74; x-xi. doi: 10.1016/j.idc.2004.07.010.
Pneumonia caused by Streptococcus pneumoniae is the most deadly form of community-acquired pneumonia. The death rate of bacteremic pneumococcal pneumonia has remained constant over the past 50 years. Several retrospective reviews of bacteremic pneumococcal pneumonia suggest that dual therapy with a beta-lactam and a macrolide antimicrobial agent is associated with a lower case fatality rate than therapy with a beta-lactam alone. These studies are reviewed, potential mechanisms are suggested, and future studies are discussed.
由肺炎链球菌引起的肺炎是社区获得性肺炎最致命的形式。在过去50年中,菌血症性肺炎球菌肺炎的死亡率一直保持不变。几项关于菌血症性肺炎球菌肺炎的回顾性研究表明,与单独使用β-内酰胺类药物治疗相比,β-内酰胺类药物与大环内酯类抗菌药物联合治疗的病死率更低。本文对这些研究进行了综述,提出了潜在机制,并讨论了未来的研究方向。