减数分裂重组：在连接处巩固配对关系。

Meiotic recombination: sealing the partnership at the junction.

作者信息

Kunz Christophe, Schär Primo

机构信息

Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Switzerland.

出版信息

Curr Biol. 2004 Nov 23;14(22):R962-4. doi: 10.1016/j.cub.2004.10.043.

DOI:10.1016/j.cub.2004.10.043

PMID:15556855

Abstract

Crossovers ensure proper chromosome segregation in meiosis. A heterodimer of MutS proteins, hMSH4-hMSH5, has recently been found to interact with recombination intermediates in a manner that suggests a mechanism for directing meiotic DNA double strand break repair towards a crossover pathway.

摘要

交叉互换确保减数分裂过程中染色体的正确分离。最近发现，MutS蛋白的异二聚体hMSH4-hMSH5以一种暗示将减数分裂DNA双链断裂修复导向交叉互换途径机制的方式与重组中间体相互作用。