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The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions.

作者信息

Hollingsworth Nancy M, Brill Steven J

机构信息

Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794-5215, USA.

出版信息

Genes Dev. 2004 Jan 15;18(2):117-25. doi: 10.1101/gad.1165904.

DOI:10.1101/gad.1165904
PMID:14752007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1851908/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/7b2021668606/nihms-18324-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/0f5b79b04b3c/nihms-18324-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/b07d559d97d8/nihms-18324-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/e10545a8cc1d/nihms-18324-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/7cfab7e2c684/nihms-18324-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/7b2021668606/nihms-18324-0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/0f5b79b04b3c/nihms-18324-0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/b07d559d97d8/nihms-18324-0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/e10545a8cc1d/nihms-18324-0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/7cfab7e2c684/nihms-18324-0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b016/1851908/7b2021668606/nihms-18324-0005.jpg

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本文引用的文献

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Fission yeast Mus81.Eme1 Holliday junction resolvase is required for meiotic crossing over but not for gene conversion.裂殖酵母Mus81.Eme1霍利迪连接体解离酶是减数分裂交叉所必需的，但不是基因转换所必需的。
Genetics. 2003 Dec;165(4):2289-93. doi: 10.1093/genetics/165.4.2289.
2
Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localization.酿酒酵母Mus81-Mms4核酸内切酶复合物形成及核定位所需的功能结构域。
DNA Repair (Amst). 2003 Dec 9;2(12):1435-47. doi: 10.1016/j.dnarep.2003.08.013.
3
Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells.
Nucleic Acids Res. 2025 Feb 27;53(5). doi: 10.1093/nar/gkaf157.
4
The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in .保守的ATP酶PCH-2通过拮抗交叉的形成来控制交叉的数量和分布。
Elife. 2025 Feb 18;13:RP102409. doi: 10.7554/eLife.102409.
5
Interference length reveals regularity of crossover placement across species.干扰长度揭示了物种间交叉放置的规律性。
Nat Commun. 2024 Oct 17;15(1):8973. doi: 10.1038/s41467-024-53054-2.
6
The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in .保守的ATP酶PCH-2通过拮抗交叉的形成来控制交叉的数量和分布。
bioRxiv. 2024 Dec 19:2024.08.13.607819. doi: 10.1101/2024.08.13.607819.
7
Formation of Different Polyploids Through Disrupting Meiotic Crossover Frequencies Based on cntd1 Knockout in Zebrafish.基于 cntd1 基因敲除在斑马鱼中破坏减数分裂交叉频率形成不同的多倍体。
Mol Biol Evol. 2024 Mar 1;41(3). doi: 10.1093/molbev/msae047.
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COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in C. elegans.COSA-1 介导的前交叉复合物形成促进了秀丽隐杆线虫减数分裂的交叉。
Nucleic Acids Res. 2024 May 8;52(8):4375-4392. doi: 10.1093/nar/gkae130.
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Homologous Recombination and Repair Functions Required for Mutagenicity during Yeast Meiosis.酵母减数分裂过程中诱变所需的同源重组和修复功能。
Genes (Basel). 2023 Oct 28;14(11):2017. doi: 10.3390/genes14112017.
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Meiotic recombination is confirmed to be unusually high in the fission yeast .减数分裂重组在裂殖酵母中被证实异常高。
iScience. 2023 Aug 11;26(9):107614. doi: 10.1016/j.isci.2023.107614. eCollection 2023 Sep 15.
Mus81核酸内切酶定位于人S期细胞的核仁及DNA损伤区域。
Mol Biol Cell. 2003 Dec;14(12):4826-34. doi: 10.1091/mbc.e03-05-0276.
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Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.在芽殖酵母减数分裂双链断裂修复的调控中，Mek1激酶活性在RED1下游发挥作用。
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5
Holliday junctions in the eukaryotic nucleus: resolution in sight?真核细胞核中的霍利迪连接体：有望得到解决？
Trends Biochem Sci. 2003 Oct;28(10):548-57. doi: 10.1016/j.tibs.2003.08.011.
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Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis.通过有切口的霍利迪连接体的拆分产生交叉：Mus81-Eme1在减数分裂中的作用
Mol Cell. 2003 Sep;12(3):761-74. doi: 10.1016/s1097-2765(03)00343-5.
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The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.内源性Mus81-Eme1复合物通过切口和反切口机制解析霍利迪连接体。
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The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast.Mus81/Mms4核酸内切酶在芽殖酵母减数分裂过程中独立于双Holliday连接体的解离发挥作用，以促进特定的交叉子集。
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Mol Cell Biol. 2003 May;23(10):3487-96. doi: 10.1128/MCB.23.10.3487-3496.2003.