早发性多发性硬化症的脑脊液特征
CSF characteristics in early-onset multiple sclerosis.
作者信息
Pohl D, Rostasy K, Reiber H, Hanefeld F
机构信息
Department of Pediatrics and Pediatric Neurology, Georg-August-University Goettingen, Robert-Koch-Strasse 40, 37075 Goettingen, Germany.
出版信息
Neurology. 2004 Nov 23;63(10):1966-7. doi: 10.1212/01.wnl.0000144352.67102.bc.
The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood-CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.
作者研究了136例发病年龄在16岁之前的多发性硬化症（MS）患者的脑脊液特征。在初始诊断性腰椎穿刺中，66%的早发型MS（EOMS）患者出现脑脊液细胞增多，13%出现血脑屏障功能障碍，92%出现寡克隆IgG。脑脊液寡克隆IgG对儿童MS的早期诊断有支持作用，其敏感性与成人发病的MS相似。
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