Pastore Luca, De Benedittis Michele, Petruzzi Massimo, Tatò Daniela, Napoli Christian, Montagna Maria Teresa, Catassi Carlo, Serpico Rosario
Dipartimento di Odontostomatologia e Chirurgia, Università, Bari.
Recenti Prog Med. 2004 Oct;95(10):482-90.
The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of the associated clinical manifestations and the often atypical or silent presentation of this disease, which makes clinical diagnosis difficult. Also oral manifestations, mostly recurrent apthous stomatitis (RAS) and dental enamel hypoplasia, are atypical signs of CD. Our opinion about the possibility of performing mass-screening to reveal atypical or silent CD is in agreement whit who is asserting that a sistematical case-finding is, at present, the most suitable epidemiological approach. So, we think that patients affected by RAS, or dental enamel hypoplasia, should be considered, even in the absence of any gastrointestinal symptom, at-risk subjects, and should therefore undergo diagnostic procedure for CD.
关于乳糜泻（CD）的知识取得了显著进展，这揭示了该疾病相关临床表现的模式以及其常常不典型或隐匿的表现形式，这使得临床诊断变得困难。口腔表现，主要是复发性阿弗他口炎（RAS）和牙釉质发育不全，也是CD的非典型体征。我们对于进行大规模筛查以发现不典型或隐匿性CD可能性的看法，与那些主张系统病例发现是目前最合适的流行病学方法的观点一致。因此，我们认为，即使没有任何胃肠道症状，患有RAS或牙釉质发育不全的患者也应被视为高危人群，因此应接受CD的诊断程序。
