Misri Shaila, Oberlander Tim F, Fairbrother Nichole, Carter Diana, Ryan Deirdre, Kuan Annie J, Reebye Pratibha
Department of Psychiatry, University of British Columbia, Vancouver.
Can J Psychiatry. 2004 Oct;49(10):684-9. doi: 10.1177/070674370404901006.
To examine the relation between the mood and anxiety of pregnant, psychiatrically treated women and neonatal health outcomes after birth.
We prospectively assessed 46 women treated with psychotropic medications for anxiety and depression during pregnancy. We compared measures of maternal mental health with infant outcomes, in particular, the outcomes of infants with symptoms of poor neonatal adaptation.
The mothers of babies who demonstrated poor neonatal adaptation reported higher levels of anxiety and depression at study entry than did the mothers of healthy babies. This relation was not related to the presence or absence of treatment with clonazepam, an anxiolytic used to treat symptoms of anxiety. Further, increased psychiatric comorbidity in the mother was associated with a greater likelihood of transient symptoms in the newborn.
Despite psychiatric treatment, the intensity and degree of comorbid symptoms appear to be related to poor transient neonatal health outcome. Our data suggest that, in addition to the impact of pharmacologic factors, maternal psychiatric status influences infant outcomes.
探讨接受精神科治疗的孕妇的情绪和焦虑与产后新生儿健康结局之间的关系。
我们前瞻性地评估了46名在孕期接受精神药物治疗以缓解焦虑和抑郁的女性。我们将母亲心理健康指标与婴儿结局进行比较，特别是与有新生儿适应不良症状的婴儿的结局进行比较。
与健康婴儿的母亲相比，其婴儿表现出新生儿适应不良的母亲在研究开始时报告的焦虑和抑郁水平更高。这种关系与是否使用用于治疗焦虑症状的抗焦虑药氯硝西泮无关。此外，母亲精神疾病共病增加与新生儿出现短暂症状的可能性更大有关。
尽管进行了精神科治疗，但共病症状的强度和程度似乎与新生儿短暂的健康不良结局有关。我们的数据表明，除了药物因素的影响外，母亲的精神状态也会影响婴儿结局。
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