Institute of Clinical Psychology and Psychotherapy, Technische Universitaet, Dresden, Germany.
Early Hum Dev. 2010 May;86(5):305-10. doi: 10.1016/j.earlhumdev.2010.04.004. Epub 2010 May 23.
Maternal perinatal mental health has been shown to be associated with adverse consequences for the mother and the child. However, studies considering the effect of DSM-IV anxiety disorders beyond maternal self-perceived distress during pregnancy and its timing are lacking.
To examine the role of maternal anxiety disorders with an onset before birth and self-perceived distress during pregnancy for unfavourable maternal, obstetric, neonatal and childhood outcomes.
DSM-IV mental disorders and self-perceived distress of 992 mothers as well as obstetric, neonatal and childhood outcomes of their offspring were assessed in a cohort sampled from the community using the Munich-Composite International Diagnostic Interview. Logistic regression analyses revealed associations (odds ratios) between maternal anxiety disorders and self-perceived distress during pregnancy with maternal depression after birth and a range of obstetric, neonatal and childhood psychopathological outcomes.
Lifetime maternal anxiety disorders were related to offspring anxiety disorders, but not to offspring externalizing disorders. Analyses focussing on maternal DSM-IV anxiety disorders before birth yielded associations with incident depression after birth. In addition, self-perceived distress during pregnancy was associated with maternal depression after birth, preterm delivery, caesarean section, separation anxiety disorder, ADHD, and conduct disorder in offspring.
Findings confirm the transmission of anxiety disorders from mother to offspring. Apart from maternal anxiety, self-perceived distress during pregnancy also emerged as a putative risk factor for adverse outcomes. The finding that maternal anxiety disorders before birth yielded less consistent associations, suggests that self-perceived distress during pregnancy might be seen as a putative moderator/mediator in the familial transmission of anxiety.
围产期母婴心理健康与母婴不良后果有关。然而，目前缺乏研究考虑 DSM-IV 焦虑障碍除了母亲怀孕期间自我感知的困扰及其时间之外的影响。
研究产前发病的母亲焦虑障碍和怀孕期间自我感知的困扰对不良母婴、产科、新生儿和儿童结局的作用。
使用慕尼黑综合国际诊断访谈从社区中抽取的队列评估了 992 名母亲的 DSM-IV 精神障碍和自我感知的困扰以及她们后代的产科、新生儿和儿童心理病理结局。逻辑回归分析显示，母亲焦虑障碍和怀孕期间自我感知的困扰与产后抑郁以及一系列产科、新生儿和儿童心理病理结局之间存在关联（优势比）。
终生母亲焦虑障碍与后代焦虑障碍有关，但与后代外化障碍无关。聚焦于产前 DSM-IV 母亲焦虑障碍的分析与产后新发抑郁有关。此外，怀孕期间自我感知的困扰与产后抑郁、早产、剖宫产、分离焦虑障碍、ADHD 和品行障碍有关。
研究结果证实了焦虑障碍从母亲到后代的传递。除了母亲的焦虑之外，怀孕期间自我感知的困扰也成为不良结局的一个潜在危险因素。产前母亲焦虑障碍产生的关联不那么一致，这表明怀孕期间自我感知的困扰可能被视为焦虑家族传递的潜在调节/中介因素。
