Szabó Zoltán, Osz Erzsébet, Lóránd Tamás
Department of Biochemistry and Medical Chemistry, Faculty of Medicine, University of Pécs, PO Box 99, H-7601 Pécs, Hungary.
J Biochem Biophys Methods. 2004 Oct 29;61(1-2):77-93. doi: 10.1016/j.jbbm.2004.04.005.
To prepare effective PARP [poly(ADP)-ribose)polymerase-1] inhibitors, starting from 2-mercapto-4(3H)-quinazolone (1), several S-alkyl derivatives--2-alkylsulfanyl-3H-quinazolin-4-ones (2-5, 7-9)--as well as an S-benzyl derivative (10) were prepared using a simple alkylation method. Some of them are known compounds. Their structure was studied thoroughly by MS and NMR methods.
