外源性核苷是马来布鲁线虫这种人类丝虫寄生虫形态发生所必需的。

Exogenous nucleosides are required for the morphogenesis of the human filarial parasite Brugia malayi.

作者信息

Rajan T V

机构信息

Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, USA.

出版信息

J Parasitol. 2004 Oct;90(5):1184-5. doi: 10.1645/GE-308R.

DOI:10.1645/GE-308R

PMID:15562627

Abstract

The nematode parasites Wuchereria bancrofti, Brugia malayi, and B. timori cause a human disease known as lymphatic filariasis, which afflicts approximately 120 million people worldwide. The parasites enter the human host from the mosquito as L3 or infective larvae and subsequently differentiate through 2 molts. In this communication, I report that B. malayi and B. pahangi depend on an exogenous source of at least 1 purine and 1 pyrimidine nucleoside to complete the L3 to L4 molt. The requirement for exogenous nucleosides opens the door for possible chemotherapeutic intervention.

摘要

线虫寄生虫班氏吴策线虫、马来布鲁线虫和帝汶布鲁线虫会引发一种名为淋巴丝虫病的人类疾病，全球约有1.2亿人受其折磨。这些寄生虫以L3期或感染性幼虫的形式从蚊子进入人类宿主，随后经过两次蜕皮进行分化。在本通讯中，我报告称，马来布鲁线虫和彭亨布鲁线虫完成L3期到L4期的蜕皮依赖于至少一种嘌呤和一种嘧啶核苷的外源供应。对外源核苷的需求为可能的化疗干预打开了大门。