Rajan T V, Paciorkowski Natalia, Kalajzic Ivo, McGuiness Carol
Department of Pathology, UConn Health Center, Farmington, Connecticut 06030-3105, USA.
J Parasitol. 2003 Aug;89(4):868-70. doi: 10.1645/GE-3137RN.
The nematode parasites Wuchereria bancrofti, Brugia malayi, and B. timori cause a disease in humans known as lymphatic filariasis, which afflicts approximately 120 million people worldwide. The parasites enter the human host from the mosquito either as L3 or as infective larvae and subsequently differentiate through 2 molts. In this article, we show that B. malayi depends on an exogenous source of vitamin C to complete the L3 to L4 molt, a critical morphogenic step in its life cycle. Brugia malayi apparently belongs to a small group of living organisms that depend on an exogenous source of vitamin C. This group includes only primates (including man) and guinea pigs among mammals.
线虫寄生虫班氏吴策线虫、马来布鲁线虫和帝汶布鲁线虫会引发人类的一种疾病，称为淋巴丝虫病，全球约有1.2亿人受其折磨。这些寄生虫以L3期或感染性幼虫的形式从蚊子进入人类宿主，随后经过2次蜕皮进行分化。在本文中，我们表明马来布鲁线虫依赖外源维生素C来完成从L3期到L4期的蜕皮，这是其生命周期中的一个关键形态发生步骤。马来布鲁线虫显然属于一小群依赖外源维生素C的生物。在哺乳动物中，这个群体仅包括灵长类动物（包括人类）和豚鼠。
