正电子发射断层扫描/计算机断层扫描下肋间呼吸肌对2-脱氧-2-[18F]氟-D-葡萄糖的摄取：吸烟者与非吸烟者的比较
2-Deoxy-2-[18F] fluoro-D-glucose uptake in intercostal respiratory muscles on positron emission tomography/computed tomography: smokers versus nonsmokers.
作者信息
Jacene Heather A, Patel Pavni P, Chin Bennett B
机构信息
The Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
出版信息
Mol Imaging Biol. 2004 Nov-Dec;6(6):405-10. doi: 10.1016/j.mibio.2004.08.002.
PURPOSE
The purpose of this study was to determine the frequency of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake in the intercostal respiratory muscles (ICM) of smokers versus nonsmokers using positron emission tomography (PET).
PROCEDURES
Ninety-six whole-body PET/computed tomography (CT) scans were retrospectively reviewed; 61 studies were from smokers and 35 from nonsmokers. The ICM uptake from the lung apices to the level of the carina was visually scored with respect to FDG intensity as follows: 0 = uptake less than or equal to lung uptake; 1 = greater than lung, but less than mediastinal blood pool; 2 = equal to mediastinal blood pool; and 3 = greater than mediastinal blood pool.
RESULTS
In smokers, 30 out of 61 (49.2%) PET/CT scans had uptake that localized to ICM, compared to 3/35 (8.6%) studies in nonsmokers. Average ICM uptake was significantly different between smokers and nonsmokers (0.787 +/- 0.933 and 0.143 +/- 0.494, respectively; P < 0.01).
CONCLUSION
Increased FDG uptake in ICM is a physiologic pattern of uptake that is frequently seen and is more common in smokers.
目的
本研究的目的是使用正电子发射断层扫描（PET）确定吸烟者与非吸烟者肋间呼吸肌（ICM）中2-脱氧-2-[18F]氟-D-葡萄糖（FDG）摄取的频率。
程序
回顾性分析了96例全身PET/计算机断层扫描（CT）；61例研究来自吸烟者，35例来自非吸烟者。根据FDG强度对从肺尖到隆突水平的ICM摄取进行视觉评分如下：0 =摄取小于或等于肺摄取；1 =大于肺摄取，但小于纵隔血池；2 =等于纵隔血池；3 =大于纵隔血池。
结果
在吸烟者中，61例PET/CT扫描中有30例（49.2%）的摄取定位于ICM，相比之下，非吸烟者的35例研究中有3例（8.6%）。吸烟者和非吸烟者的平均ICM摄取有显著差异（分别为0.787±0.933和0.143±0.494；P<0.01）。
结论
ICM中FDG摄取增加是一种常见的生理摄取模式，在吸烟者中更常见。
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