Terayama Hayato, Itoh Masahiro, Fukunishi Isao, Iwahashi Kazuhiko
First Department of Anatomy, School of Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
Psychiatr Genet. 2004 Dec;14(4):195-7. doi: 10.1097/00041444-200412000-00005.
Epidemiological and genetic studies on smoking behavior have been performed, and in this study the human serotonin 2A receptor (HTR2A) polymorphism was examined in 82 smoking behaviorists and 125 healthy controls. HTR2A consists of at least 14 subtypes, depression and anxiety occur due to agonists, and hallucination, fever heat, psychomotor excitement and other symptoms also occur. The polymorphism in HTR2A (102T/C, -1438A/G) was identified by means of the polymerase chain reaction followed by restriction fragment length polymorphism, and the Fagerstrom Test for Nicotine Dependence was used to determine the extent of smoking behavior. The results suggest that the HTR2A (102T/C, -1438G/A) polymorphism might not be associated with susceptibility to a risk factor for developing smoking behavior. Further studies are required to determine whether or not the novel serotonin receptor (5-HTR) polymorphism reflects the pathogenesis of smoking behavior.
已经开展了关于吸烟行为的流行病学和遗传学研究，在本研究中，对82名吸烟行为者和125名健康对照者进行了人类5-羟色胺2A受体（HTR2A）多态性检测。HTR2A至少由14种亚型组成，激动剂可导致抑郁和焦虑，还会出现幻觉、发热、精神运动性兴奋等症状。通过聚合酶链反应和限制性片段长度多态性鉴定HTR2A（102T/C，-1438A/G）的多态性，采用尼古丁依赖的Fagerstrom测试来确定吸烟行为的程度。结果表明，HTR2A（102T/C，-1438G/A）多态性可能与吸烟行为发生风险因素的易感性无关。需要进一步研究以确定新型5-羟色胺受体（5-HTR）多态性是否反映吸烟行为的发病机制。
