Ando Tetsuya, Kodama Naoki, Ishikawa Toshio, Naruo Tetsuro, Tachikawa Naoko, Nozaki Takehiro, Okabe Kenjiro, Takeuchi Kaori, Masuda Akinori, Kawamura Noriyuki, Komaki Gen
Division of Psychosomatic Research, National Institute of Mental Health, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Chiba, Japan.
Psychiatr Genet. 2004 Dec;14(4):215-8. doi: 10.1097/00041444-200412000-00009.
Energy expenditure abnormalities have been observed in anorexia nervosa (AN). The uncoupling proteins (UCPs) have been implicated as having a role in energy metabolism and thermogenesis, and an association between a marker flanking the UCP-2/UCP-3 gene cluster and AN has been reported. Also known are insertion/deletion and -866G/A polymorphisms in the UCP-2 gene, and the -55C/T polymorphism in the UCP-3 gene. Differences in these alleles are reportedly related to changes in energy expenditure, body mass index, fat tissue accumulation and obesity. Therefore, this case-control association analysis was done to determine whether any of these UCP-2/3 gene polymorphisms are related to a predisposition to AN. In analysis of a cohort of 106 female Japanese AN sufferers and 126 normal female controls, we found no between-group differences in the polymorphism frequencies of these groups. The hypothesis that differences in the UCP-2/3 gene influence the susceptibility to AN was not supported.
在神经性厌食症（AN）中已观察到能量消耗异常。解偶联蛋白（UCPs）被认为在能量代谢和产热中起作用，并且有报道称UCP - 2/UCP - 3基因簇侧翼的一个标记与AN之间存在关联。UCP - 2基因中的插入/缺失和 - 866G/A多态性以及UCP - 3基因中的 - 55C/T多态性也为人所知。据报道，这些等位基因的差异与能量消耗、体重指数、脂肪组织积累和肥胖的变化有关。因此，进行了这项病例对照关联分析，以确定这些UCP - 2/3基因多态性是否与AN的易感性有关。在对106名日本女性AN患者和126名正常女性对照的队列分析中，我们发现这些组的多态性频率在组间没有差异。UCP - 2/3基因差异影响AN易感性的假设未得到支持。
