Fukuda Shinsaku, Shimoyama Tadashi, Umegaki Noriko, Mikami Tatsuya, Nakano Hajime, Munakata Akihiro
First Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, 036-8562 Hirosaki, Japan.
J Gastroenterol. 2004 Sep;39(9):827-30. doi: 10.1007/s00535-004-1397-7.
Infection with Helicobacter pylori has been associated with chronic idiopathic urticaria (CIU). The aim of this study was to investigate the efficacy of H. pylori eradication in the treatment of patients with CIU.
Fifty patients with CIU (16 men and 34 women; age 25-75 years) and 100 sex- and age-matched control subjects were enrolled in the study. Presence of IgG antibody to H. pylori was examined by serology. H. pylori-seropositive patients with CIU received endoscopy to confirm H. pylori infection. Patients infected with H. pylori received eradication therapy comprising lansoprazole, amoxicillin, and either clarithromycin or metronidazole. At least 2 months after finishing the eradication therapy, a (13)C-urea breath test was performed, and the effect of eradication therapy on the CIU was scored, using a three-point scale, as complete remission, partial remission, or no improvement.
In the 50 patients with CIU, 26 (52%) were H. pylori-seropositive, while 48% (48/100) of the control subjects were seropositive (statistically not significant). Nineteen out of the 26 patients with CIU infected with H. pylori received eradication therapy, and eradication was successful in 17 patients. In the 17 H. pylori-eradicated patients, 6 (35%) had complete remission and 11 (65%) had complete remission or partial remission. On the other hand, in the 9 patients without H. pylori eradication, only 2 (22%) showed partial remission and 7 (78%) had no improvement.
Eradication of H. pylori would be a valid choice for patients with CIU, although the prevalence of H. pylori infection is not higher in patients with CIU than it is in controls.
幽门螺杆菌感染与慢性特发性荨麻疹（CIU）有关。本研究旨在探讨根除幽门螺杆菌治疗CIU患者的疗效。
本研究纳入了50例CIU患者（16例男性和34例女性；年龄25 - 75岁）和100例年龄及性别匹配的对照者。通过血清学检测幽门螺杆菌IgG抗体的存在情况。CIU且幽门螺杆菌血清学阳性的患者接受内镜检查以确认幽门螺杆菌感染。感染幽门螺杆菌的患者接受包含兰索拉唑、阿莫西林以及克拉霉素或甲硝唑的根除治疗。在完成根除治疗至少2个月后，进行（13）C - 尿素呼气试验，并使用三分制对根除治疗对CIU的效果进行评分，分为完全缓解、部分缓解或无改善。
在50例CIU患者中，26例（52%）幽门螺杆菌血清学阳性，而对照者中有48%（48/100）血清学阳性（无统计学意义）。26例感染幽门螺杆菌的CIU患者中有19例接受了根除治疗，17例治疗成功。在17例根除幽门螺杆菌的患者中，6例（35%）完全缓解，11例（65%）完全缓解或部分缓解。另一方面，在9例未根除幽门螺杆菌的患者中，仅2例（22%）部分缓解，7例（78%）无改善。
对于CIU患者，根除幽门螺杆菌是一种有效的选择，尽管CIU患者中幽门螺杆菌感染率并不高于对照组。
