Goldberg Martin
University of Durham, School of Biological and Biomedical Sciences, Science Laboratories, UK.
Symp Soc Exp Biol. 2004(56):115-33.
Eukaryotic cells transport a myriad of molecules between the nucleus and cytoplasm and have evolved a number of related biochemical pathways to achieve this, many of which have been elucidated in recent years. One central and common component to all the pathways is the NPC. NPC components appear to play vital roles in transport and the NPC is structurally dynamic, but whether its role is as a facilitator, a controller or both is yet to be decided and awaits further analysis on the role of individual components in specific pathways.
真核细胞在细胞核和细胞质之间运输大量分子，并进化出了许多相关的生化途径来实现这一点，其中许多途径在近年来已得到阐明。所有这些途径的一个核心且共同的组成部分是核孔复合体（NPC）。NPC的组成部分似乎在运输过程中发挥着至关重要的作用，并且NPC在结构上是动态的，但其作用是作为促进者、控制者还是两者兼具，仍有待确定，需要进一步分析各个组成部分在特定途径中的作用。
