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A review of the effects of the oral direct thrombin inhibitor ximelagatran on coagulation assays.

作者信息

Carlsson Stefan C, Mattsson Christer, Eriksson Ulf G, Sarich Troy C, Wåhlander Karin, Eliasson Asa, Karlson Björn W, Sheth Sunita B, Held Peter

机构信息

AstraZeneca R&D Mölndal, Mölndal, Sweden.

出版信息

Thromb Res. 2005;115(1-2):9-18. doi: 10.1016/j.thromres.2004.07.001.

DOI:10.1016/j.thromres.2004.07.001
PMID:15567447
Abstract
摘要

相似文献

1
A review of the effects of the oral direct thrombin inhibitor ximelagatran on coagulation assays.
Thromb Res. 2005;115(1-2):9-18. doi: 10.1016/j.thromres.2004.07.001.
2
A step change in oral anticoagulation: lack of coagulation monitoring with ximelagatran.口服抗凝治疗的一个重大转变：希美加群无需凝血监测。
Semin Vasc Med. 2005 Aug;5(3):259-65. doi: 10.1055/s-2005-916165.
3
Discovery of ximelagatran in an historical perspective.从历史角度看希美加群的发现。
Semin Vasc Med. 2005 Aug;5(3):227-34. doi: 10.1055/s-2005-916161.
4
Mechanism of action of the oral direct thrombin inhibitor ximelagatran.口服直接凝血酶抑制剂希美加群的作用机制。
Semin Vasc Med. 2005 Aug;5(3):235-44. doi: 10.1055/s-2005-916162.
5
Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination.口服直接凝血酶抑制剂希美加群的活性形式美拉加群在脐带血和成人血浆中的抗凝作用：一项体外研究。
Thromb Res. 2005;115(1-2):135-42. doi: 10.1016/j.thromres.2004.07.003.
6
Ximelagatran: oral direct thrombin inhibition as anticoagulant therapy in atrial fibrillation.希美加群：口服直接凝血酶抑制用于心房颤动的抗凝治疗
J Am Coll Cardiol. 2005 Jan 4;45(1):1-9. doi: 10.1016/j.jacc.2004.09.049.
7
Ximelagatran: pharmacokinetics and pharmacodynamics of a new strategy for oral direct thrombin inhibition.
Rev Cardiovasc Med. 2004;5 Suppl 5:S4-11.
8
The respective and combined anticoagulant effects of recombinant human activated protein C, melagatran and heparins using CAT.使用凝血酶抗凝血活性测定法检测重组人活化蛋白C、美拉加群和肝素各自的及联合的抗凝作用。
Thromb Res. 2007;119(3):361-7. doi: 10.1016/j.thromres.2006.03.004. Epub 2006 May 19.
9
A combination of a thrombin inhibitor and dexamethasone prevents the development of experimental disseminated intravascular coagulation in rats.凝血酶抑制剂与地塞米松联合使用可预防大鼠实验性弥散性血管内凝血的发生。
Thromb Res. 2006;117(4):429-37. doi: 10.1016/j.thromres.2005.03.014.
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Low potential for interactions between melagatran/ximelagatran and other drugs, food, or alcohol.美拉加群/希美加群与其他药物、食物或酒精之间发生相互作用的可能性较低。
Semin Vasc Med. 2005 Aug;5(3):254-8. doi: 10.1055/s-2005-916164.

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心房颤动的卒中预防：概念与争议
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Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.口服直接凝血酶抑制剂和Xa因子抑制剂在研的比较药效学和药代动力学
Clin Pharmacokinet. 2009;48(1):1-22. doi: 10.2165/0003088-200948010-00001.
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Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects.直接口服凝血酶抑制剂达比加群在健康老年受试者中的药代动力学和药效学
Clin Pharmacokinet. 2008;47(1):47-59. doi: 10.2165/00003088-200847010-00005.
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Effect of low and high dose melagatran and other antithrombotic drugs on platelet aggregation.低剂量和高剂量美拉加群及其他抗血栓药物对血小板聚集的影响。
J Thromb Thrombolysis. 2008 Apr;25(2):198-203. doi: 10.1007/s11239-007-0085-x. Epub 2007 Aug 21.
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The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects.新型口服直接凝血酶抑制剂达比加群酯在健康男性受试者中的药代动力学、药效学及耐受性
Br J Clin Pharmacol. 2007 Sep;64(3):292-303. doi: 10.1111/j.1365-2125.2007.02899.x. Epub 2007 May 15.
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Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis.直接凝血酶抑制剂达比加群对骨科手术患者体外凝血时间的影响：一项群体模型分析
Br J Clin Pharmacol. 2006 Nov;62(5):527-37. doi: 10.1111/j.1365-2125.2006.02667.x.