Young Yi-Ho, Kuo Shih-Wei
Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, 1 Chang-Te Street, Taipei, Taiwan.
Hear Res. 2004 Dec;198(1-2):93-8. doi: 10.1016/j.heares.2004.06.011.
The aim of this study was to investigate the side-difference of vestibular evoked myogenic potentials (VEMPs) in relation to the provocation rates, latencies and amplitudes using binaural acoustic stimulation with bilateral recording. Fourteen healthy volunteers underwent a serial VEMP testings elicited binaurally by a sequence of alternating stimulus intensities, that is, 95-95 (right-left), 85-95, 95-85, and 85-85 dBHL tone burst, respectively. The provocation rates as well as the mean latencies of p13 and n23 for the VEMPs demonstrated no significant side-difference despite using 95-95, 85-95, 95-85 and 85-85 dBHL binaural acoustic stimulation. In contrast, nine (64%) of the 14 subjects showed side-difference of absolute p13-n23 amplitude, including right side dominant in five subjects, and left side dominant in four subjects. However, there was no significant side-difference in terms of relative amplitude despite using 95-95, 85-95, 95-85 and 85-85 dBHL binaural acoustic stimulation. Furthermore, the relative amplitude or interaural amplitude difference (IAD) ratios between those with and without side-difference of p13-n23 amplitude did not differ significantly. Hence, this study provides a potentially important method for adjusting the side difference of p13-n23 amplitudes by using a relative amplitude or IAD ratio adjustment. It also adds confidence to the successful use of binaural stimulation and recording of VEMPs under conditions of bilateral SCM muscular contractions.
本研究的目的是通过双耳记录的双耳听觉刺激，研究前庭诱发肌源性电位（VEMP）在激发率、潜伏期和振幅方面的左右差异。14名健康志愿者接受了一系列VEMP测试，通过一系列交替的刺激强度双耳诱发，即分别为95 - 95（右 - 左）、85 - 95、95 - 85和85 - 85 dBHL短纯音。尽管使用了95 - 95、85 - 95、95 - 85和85 - 85 dBHL双耳听觉刺激，但VEMP的激发率以及p13和n23的平均潜伏期均未显示出明显的左右差异。相比之下，14名受试者中有9名（64%）表现出绝对p13 - n23振幅的左右差异，其中5名受试者右侧占优势，4名受试者左侧占优势。然而，尽管使用了95 - 95、85 - 95、95 - 85和85 - 85 dBHL双耳听觉刺激，相对振幅方面没有明显的左右差异。此外，p13 - n23振幅有左右差异和无左右差异的受试者之间的相对振幅或耳间振幅差（IAD）比率没有显著差异。因此，本研究提供了一种潜在的重要方法，即通过使用相对振幅或IAD比率调整来调节p13 - n23振幅的左右差异。它还为在双侧胸锁乳突肌收缩条件下成功使用双耳刺激和记录VEMP增加了信心。
