[含碘食物对Graves病患者99mTc和131I摄取的影响]

[Effects of iodine-containing food on 99mTc and 131I uptake in patients with Graves' disease].

作者信息

He Guo-rong, Ouyang Wei, Liu Jin-hua, Liu Wei-ying

机构信息

Department of Nuclear Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 51028, China.

出版信息

Di Yi Jun Yi Da Xue Xue Bao. 2004 Nov;24(11):1292-4.

PMID:15567783

Abstract

OBJECTIVE

To investigate the changes in 99mTc and 131I uptake in patients with Grave's disease after intake of iodine-containing food. METGIDSl The 3-hour and 24-hour radioactive iodine uptake (RAIU) and 99mTc uptake ratio (TI) were measured and the thyroid weight (TW) was estimated in 20 patients with Graves' disease both before and after restraint of iodine-containing diet.

RESULTS

Significant difference was found in RAIU and TI in patients after restraint of iodine-rich diet (Z=3.920, P=0.000 for 3-hour RAIU and Z=3.920, P=0.000 for 24-hour RAIU; Z=2.199, P=0.028 for TI and Z=3.920, P=0.000 for TW estimated from 99mTc images). The tendency in such changes was significantly different (Z=4.066, P=0.000 for RAIU and TI; Z=4.243, P=0.000 for RAIU and TW). After restraint of iodine-rich food, RAIU of 3-hour and 24-hour increased in all the patients, and TI decreased in 16, remained the same level in 2 and increased in 2 patients; TW decreased in 18 and increased in 2 patients.

CONCLUSION

Iodine-containing food has different effects on thyroid 131I and 99mTc uptakes, which decreases 131I uptake in all the patients and increases 99mTc in 90% of them.

摘要

目的

研究格雷夫斯病患者摄入含碘食物后99mTc和131I摄取的变化。方法：测量20例格雷夫斯病患者在限制含碘饮食前后的3小时和24小时放射性碘摄取率（RAIU）以及99mTc摄取率（TI），并估算甲状腺重量（TW）。

结果

限制富碘饮食后患者的RAIU和TI有显著差异（3小时RAIU：Z = 3.920，P = 0.000；24小时RAIU：Z = 3.920，P = 0.000；TI：Z = 2.199，P = 0.028；根据99mTc图像估算的TW：Z = 3.920，P = 0.000）。这些变化趋势有显著差异（RAIU和TI：Z = 4.066，P = 0.000；RAIU和TW：Z = 4.243，P = 0.000）。限制富碘食物后，所有患者的3小时和24小时RAIU均升高，16例患者的TI降低，2例患者的TI保持不变，2例患者的TI升高；18例患者的TW降低，2例患者的TW升高。